AI Article Synopsis
- Preclinical safety tests of GB-115, a new dipeptide compound targeting cholecystokinin receptors, showed no fatalities in mice or rats after high doses.
- Long-term oral administration in rabbits and rats did not cause permanent organ damage at doses of 0.1 and 10 mg/kg.
- GB-115 exhibited no harmful effects such as allergies or mutations, and even reduced inflammation at a dose of 10 mg/kg.
Article Abstract
Preclinical safety investigations of newly synthesized dipeptide compound GB-115 (amide N-phenylhexanoyl-glycyl-L-tryptophan), an antagonist of cholecystokinin receptors, were performed. No animals were lost after GB-115 acute oral administration at a maximum dose of 6000 mg/kg in mice and at 3500 mg/kg in rats. GB-115 administered per os during 6 months in rabbits and rats (both males and females) at the doses of 0.1 and 10 mg/kg induced no irreversible pathological changes in organs and systems studied. The tested dipeptide exhibited no allergenic, immunotoxic and mutagenic activity, and did not affect generative function and the antenatal and postnatal development of progeny. GB-115 at a dose of 10 mg/kg produced suppression of the inflammatory reaction to concanavalin A.
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