Objective: To know the relationship between fever and H1N1 influenza vaccination among students.

Methods: Collect and analyze the data from Shanghai school absence reporting system and H1N1 influenza vaccine daily reporting system.

Results: 51 schools and 49024 students were investigated. The H1N1 influenza vaccine coverage rate was 58.5% among them. The fever rates for vaccinated and unvaccinated students were 2.41% and 7.49% respectively. It has statistic difference.

Conclusion: The H1N1 influenza vaccine was safe and the protection rate against fever was 68%.

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