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Hollow Fiber Microreactor Combined with Digital Twin to Optimize the Antimicrobial Evaluation Process.
Micromachines (Basel)
December 2024
Bioengineering, School of Engineering, The University of Tokyo, Tokyo 113-8656, Japan.
In order to reproduce pharmacokinetics (PK) profiles seen in vivo, the Hollow Fiber Infection Model (HFIM) is a useful in vitro module in the evaluation of antimicrobial resistance. In order to reduce the consumption of culture medium and drugs, we developed a hollow fiber microreactor applicable to the HFIM by integrating the HFIM function. Next, we constructed a novel control method by using the "digital twin" of the microreactor to achieve precise concentration control.
View Article and Find Full Text PDFNoble-Metal-Free Cocatalysts Reinforcing Hole Consumption for Photocatalytic Hydrogen Evolution with Ultrahigh Apparent Quantum Efficiency.
Adv Mater
December 2024
College of Physics and Center of Quantum Materials and Devices, Chongqing University, Chongqing, 401331, China.
Achieving efficient and sustainable hydrogen production through photocatalysis is highly promising yet remains a significant challenge, especially when replacing costly noble metals with more abundant alternatives. Conversion efficiency with noble-metal-free alternatives is frequently limited by high charge recombination rates, mainly due to the sluggish transfer and inefficient consumption of photo-generated holes. To address these challenges, a rational design of noble-metal-free cocatalysts as oxidative sites is reported to facilitate hole consumption, leading to markedly increased H yield rates without relying on expensive noble metals.
View Article and Find Full Text PDFSelective Decarboxylative Fluorination of β-Keto Acids in Aqueous Media: F-NMR-Assisted Batch Optimization and Transfer to Continuous Flow.
Chemistry
December 2024
Fraunhofer Institute for Microengineering and Microsystems IMM, Carl-Zeiss-Strasse 18-20, 55129, Mainz, Germany.
The selective decarboxylative fluorination of 3-oxo-3-phenylpropionic acid is used as a benchmark reaction to optimize it under biocompatible conditions in batch and to transfer it to continuous flow mode. The reaction conditions are varied with respect to temperature, fluorinating reagents, inorganic base additives, and pH, as these parameters have been identified as having a significant impact on the process. The formation of the products and any by-products is analyzed using gas chromatography (GC) and F nuclear magnetic resonance spectroscopy (NMR).
View Article and Find Full Text PDFRecent Advances on Integrating Porous Nanomaterials with Chemiluminescence Assays.
Chem Asian J
December 2024
Nanjing University of Posts and Telecommunications, Institute of Advanced Materials, CHINA.
Advanced porous nanomaterials have recently been the subject of considerable interest due to their high surface areas, tunable pore structures, high porosity, and ease of modification. In the chemiluminescence (CL) domain, the incorporation of additional pores into nanostructures not only enhances the loading capacity for signal amplification but also allows the confinement effect in a nanoscale microreactor and the controlled release of reaction agents. In light of this, increasing efforts have been made to fabricate various porous nanomaterials and explore their potential applications in CL assays.
View Article and Find Full Text PDFSingle-Cell Secretome Profiling Enabled by Selective Enrichment and NanoLC-MS/MS Analysis.
Angew Chem Int Ed Engl
November 2024
State Key Laboratory of Medical Proteomics, National Chromatographic R. & A. Center, CAS Key Laboratory of Separation Science for Analytical Chemistry, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian, 116023, China.
Recent advances in single-cell proteomics enable the direct profiling of thousands of proteins from a single mammalian cell. However, due to the bottlenecks in detecting low-abundance secreted proteins and extracellular vesicle (EV) proteins (collectively referred to as the secretome) against a background of high-abundance proteins in serum-containing culture medium, the comprehensive investigation of the secretome at the single-cell level using nanoLC-MS/MS still remains challenging. Herein, we report a novel single-cell secretome profiling (SCSP) method by integrating the metabolic labeling of newly synthesized proteins, click chemistry-based enrichment, and in situ digestion of the labeled secretome in an alkyne-functionalized capillary micro-reactor, followed by nanoLC-MS/MS analysis.
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