The human immunodeficiency virus type 1 (HIV-1) transactivator (tat) protein produced in one cell activated HIV-1 promoter-directed gene expression in a second cell, provided the cells were in direct contact with one another. This observation suggests that the tat protein produced in HIV-1-infected cells has a physiological effect on neighboring cells.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC248903 | PMC |
| http://dx.doi.org/10.1128/JVI.65.8.4547-4549.1991 | DOI Listing |
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