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Gastrointestinal adverse events during methylphenidate treatment of children and adolescents with attention deficit hyperactivity disorder: A systematic review with meta-analysis and Trial Sequential Analysis of randomised clinical trials.
PLoS One
September 2017
Psychiatric Research Unit, Region Zealand Psychiatry, Slagelse, Denmark.
Objectives: To study in more depth the relationship between type, dose, or duration of methylphenidate offered to children and adolescents with attention deficit hyperactivity disorder and their risks of gastrointestinal adverse events based on our Cochrane systematic review.
Methods And Findings: We use data from our review including 185 randomised clinical trials. Randomised parallel-group trials and cross-over trials reporting gastrointestinal adverse events associated with methylphenidate were included.
Methylphenidate for attention-deficit/hyperactivity disorder in children and adolescents: Cochrane systematic review with meta-analyses and trial sequential analyses of randomised clinical trials.
BMJ
November 2015
Copenhagen Trial Unit, Centre for Clinical Intervention Research, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark The Cochrane Hepato-Biliary Group, Copenhagen Trial Unit, Centre for Clinical Intervention Research, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark.
Article Synopsis
- The study aimed to evaluate the benefits and risks of methylphenidate for treating ADHD in kids and teens by analyzing data from multiple clinical trials.
- The results showed methylphenidate had a positive effect on ADHD symptoms and general behavior ratings, particularly from teachers, without increasing serious adverse events, but it did raise the risk of non-serious side effects.
- However, most of the trials were deemed to have a high risk of bias, and the overall quality of the evidence was classified as very low.
Gilles de la Tourette syndrome in a cohort of deaf people.
Asian J Psychiatr
October 2015
Child and Adolescent Psychiatry, School of Psychiatry & Ingham Institute, University of New South Wales, Liverpool Hospital, L1, MHC, Elizabeth Street, 2170 Sydney, NSW, Australia. Electronic address:
We present six patients with Gilles de la Tourette syndrome (TS) who are also deaf. TS has been observed previously, but rarely reported in deaf people, and to date, so called "unusual" phenomenology has been highlighted. TS occurs almost worldwide and in all cultures, and the clinical phenomenology is virtually identical.
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