AI Article Synopsis
- A normal cerebrospinal fluid (CSF) study has been the standard method to rule out bacterial meningitis, but there have been instances of pyogenic meningitis occurring even with normal CSF pleocytosis.
- In cases where clinical signs of meningitis are present, an abnormal initial CSF study supports a bacterial meningitis diagnosis, but a normal result does not definitively exclude it.
- As a result, it is crucial to start appropriate antimicrobial treatment early, regardless of initial CSF findings.
Article Abstract
A normal initial cerebrospinal fluid (CSF) study has been traditionally used to exclude the potential diagnosis of bacterial meningitis. However, cases of pyogenic meningitis in the absence of CSF pleocytosis have been reported in which smears for gram stain or CSF culture revealed the diagnosis of meningitis. In the presence of clinical signs of meningitis, an abnormal initial CSF study indicates a diagnosis of bacterial meningitis but a normal result may not necessarily exclude it and therefore, should not delay early institution of appropriate antimicrobial therapy.
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| http://dx.doi.org/10.1007/s12098-010-0142-x | DOI Listing |
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