AI Article Synopsis
- Hyperferritinemia is frequently found in individuals with metabolic syndrome, but the relationship to tissue iron overload is not fully understood.
- A study of ten individuals with dysmetabolic hyperferritinemia showed that 70% had mild liver iron overload, while serum ferritin levels were significantly higher compared to healthy controls.
- The cases demonstrated normal transferrin saturation but elevated urinary hepcidin levels, indicating a unique profile of iron metabolism in those affected.
Article Abstract
Hyperferritinemia is common in individuals with the metabolic syndrome (dysmetabolic hyperferritinemia), but its pathophysiology and the degree to which it reflects tissue iron overload remains unclear. We conducted a cross-sectional study evaluating ten cases with dysmetabolic hyperferritinemia for liver iron overload and compared their serum iron indices and urine hepcidin levels to healthy controls. Seven out of ten cases had mild hepatic iron overload by magnetic resonance imaging (MRI) (median, 75 micromol/g dry weight). Cases had higher serum ferritin than controls (median, 672 microg/L vs. 105 microg/L, p < 0.001), but the median transferrin saturation was not significantly different (38% vs. 36%, p = 0.5). Urinary hepcidin was elevated in dysmetabolic hyperferritinemia (median; 1,584 g/mg of creatinine vs. 799 ng/mg of creatinine, p = 0.05). Dysmetabolic hyperferritinemia is characterized by hyperferritinemia with normal transferrin saturation, elevated hepcidin levels, and mild liver iron overload in a subset of patients.
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| http://dx.doi.org/10.1007/s00277-010-1050-x | DOI Listing |
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