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Detection of IgG1 and IgG4 subtypes reactive against potato apyrase in schistosomiasis patients. | LitMetric

Detection of IgG1 and IgG4 subtypes reactive against potato apyrase in schistosomiasis patients.

Mem Inst Oswaldo Cruz

Departamento de Bioquímica, Instituto de Ciências Biológicas, Laboratório de Estrutura e Função de Proteínas, Universidade Federal de Juiz de Fora, Juiz de Fora, MG, Brasil.

Published: July 2010

AI Article Synopsis

Article Abstract

In this paper, we showed for the first time that the conserved domains within Schistosoma mansoni ATP diphosphohydrolase isoforms, shared with potato apyrase, possess epitopes for the IgG1 and IgG4 subtypes, as 24 (80%) of the 30 schistosomiasis patients were seropositive for this vegetable protein. The analyses for each patient cured (n = 14) after treatment (AT) with praziquantel revealed variable IgG1 and IgG4 reactivity against potato apyrase. Different antigenic epitopes shared between the vegetable and parasite proteins could be involved in susceptibility or resistance to S. mansoni AT with praziquantel and these possibilities should be explored.

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Source
http://dx.doi.org/10.1590/s0074-02762010000400004DOI Listing

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