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Left ventricular global systolic dysfunction has a significant role in the development of diastolic heart failure in patients with systemic hypertension. | LitMetric

AI Article Synopsis

  • The study investigates the link between left ventricular (LV) systolic function and heart failure symptoms in patients with diastolic heart failure (DHF) and systemic hypertension.
  • Researchers analyzed 220 patients with systemic hypertension and 30 healthy individuals, using Doppler echocardiography to assess their heart function.
  • Findings revealed that patients with DHF had lower ejection fractions and higher isovolumetric contraction times, indicating that global LV systolic dysfunction contributes significantly to heart failure symptoms in these patients.

Article Abstract

Regional left ventricular (LV) systolic dysfunction has been identified in diastolic heart failure (DHF). However, the relationship between regional or global LV systolic function and heart failure symptoms in DHF has not been evaluated in detail. The present study evaluates such relationships in patients with systemic hypertension (HT) and DHF. We assessed LV systolic and diastolic function in 220 consecutive patients with systemic HT and in 30 normal individuals (Control) using Doppler echocardiography. Patients with HT were assigned to groups with DHF, asymptomatic diastolic dysfunction (ADD) and no diastolic dysfunction (Simple HT). Ejection fraction in DHF was significantly decreased (63±8%) compared with the Control, Simple HT and ADD groups (67±5, 66±7 and 68±8%, respectively). Isovolumetric contraction time in DHF (70±30 msec) was significantly increased compared with those in the ADD, Simple HT and Control groups (31±17, 31±15 and 30±19 msec, respectively). Mitral annular systolic velocities were significantly decreased in the DHF and ADD groups (6.4±1.5 and 7.2±1.3 cm sec⁻¹, respectively) compared with those in the Simple HT and Control groups (8.5±1.8 and 8.4±3.0 cm sec⁻¹, respectively), and in the DHF group compared with the ADD group. LV global systolic dysfunction has a significant role in the development of heart failure symptoms associated with DHF in patients with systemic HT.

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Source
http://dx.doi.org/10.1038/hr.2010.142DOI Listing

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