In-depth researches on the psychopathology of obsessive-compulsive disorder (OCD) have been made in the cognitive-behavioral domain. However, some questions about the symptoms have not been properly answered yet. Studies from other domains also shed light on the psychopathology of OCD. The most inspiring ones are studies on psychological trauma which have probed into the mechanism of intrusions, and studies on emotion regulation which have investigated how behavioral emotion expressions are shaped. In this paper, we analyze the roles of psychological trauma and emotion regulation in OCD and propose a double conflicts model. In the model, it is hypothesized that information conflict and motivational conflict, which are called "core conflicts", are key factors in the psychopathology of OCD, and that obsessions and compulsions arise within two associated loops. Anxiety ratification therapy hypothesis is further put forward, which emphasizes the acceptance of all aspects of anxiety, including the behavioral responses and the accompanying new information, and sets the modification of the basic assumptions as the goal of treatment. Although the model provides comprehensive explanation for many symptoms, the assumptions on which the model is based are in need of confirmation. The therapy is tailored for OCD, but its operability and effect should be monitored closely.
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http://dx.doi.org/10.1016/j.mehy.2010.07.039 | DOI Listing |
Microsyst Nanoeng
December 2024
Research Center for Bionic Sensing and Intelligence, Institute of Biomedical and Health Engineering, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, 518055, Shenzhen, China.
We present a versatile platform for label-free magnetic separation of plasma, tailored to accommodate diverse environments. This innovative device utilizes an advanced long-short alternating double Halbach magnetic array, specifically engineered for optimal magnetic separation. The array's adaptability allows for seamless integration with separation channels of varying sizes, enabling static separation of whole blood.
View Article and Find Full Text PDFInt J Biol Macromol
December 2024
Henan Provincial Engineering Research Center for Development and Application of Characteristic Microorganism Resources, Dried Chili Industry Technology Research Center, Department of Biology and Food Science, Shangqiu Normal University, Shangqiu, Henan 476000, China. Electronic address:
Plants frequently encounter phosphate (Pi) starvation due to its scarce availability in soil, necessitating an adaptive phosphate starvation response (PSR). This study explores this adaptation in pepper (Capsicum annuum L.) under low-Pi stress, focusing on the PHOSPHATE STARVATION RESPONSE (PHR) gene family.
View Article and Find Full Text PDFJ Neurol Sci
December 2024
Center for Advanced Neurological Research, Nitte University, Mangalore,India.
Background: Among white populations, a poly-specific antibody response against measles (M), rubella (R) and varicella zoster(Z) otherwise known as MRZR is seen in ∼70 % of MS and rarely in other demyelinating disorders. While the basis for MRZR is unclear, vaccination exposure / community acquired infections may have an influence on its frequency.
Objective: To determine the frequency and specificity of MRZR in MS and related disorders in a non- white population with historically low vaccinations and to contrast against oligoclonal bands (OCB).
Lung Cancer
December 2024
Medical Oncology Department, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy; Department of Electronics, Information and Bioengineering, Polytechnic University of Milan, Milan, Italy.
Introduction: KRAS mutation the most common molecular alteration in advanced non-small cell lung cancer (NSCLC) and is associated with an unfavourable prognosis, largely due to the lack of targeted therapeutic options for the majority of the KRAS mutated isoforms. The landscape of NSCLC treatment has expanded with the introduction of immune checkpoint inhibitors (ICIs). Nonetheless, data regarding the efficacy of ICI in NSCLC patients harbouring KRAS mutations are conflicting.
View Article and Find Full Text PDFPhotochem Photobiol Sci
December 2024
Biophysical Chemistry and Diagnostics, Department of Chemistry, Bielefeld University, Universitätsstraße 25, 33615, Bielefeld, Germany.
Flavin-dependent halogenases (FDHs) are promising candidates for the sustainable production of halogenated organic molecules by biocatalysis. FDHs require only oxygen, halide and a fully reduced flavin adenine dinucleotide (FADH) cofactor to generate the reactive HOX that diffuses 10 Å to the substrate binding pocket and enables regioselective oxidative halogenation. A key challenge for the application of FDHs is the regeneration of the FADH.
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