AI Article Synopsis
- Alzheimer's Disease (AD) is the leading cause of dementia among older adults, with no cure or long-term treatment available despite some drugs that can delay symptoms.
- The lack of effective therapies is partly due to an incomplete understanding of the disease's biochemical causes.
- Research using model organisms, particularly Drosophila (fruit flies), has provided valuable insights into the genes linked to AD and helped develop models to study the disease.
Article Abstract
Alzheimer's Disease (AD) is the most common cause of dementia in the aging population. Although a variety of drug treatments can delay the onset of disease or temporarily reduce its severity, there is currently no cure or effective long-term treatment. This therapeutic void in part reflects an incomplete understanding of the biochemical pathogenesis of this disease. Model organisms, including invertebrates, have been extensively utilized to gain insight into the molecular and cellular mechanisms underlying disease. Here, we will describe how Drosophila has been used to study the function of genes associated with AD and to develop models of this devastating disease.
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| http://dx.doi.org/10.1016/j.exger.2010.08.004 | DOI Listing |
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