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Discovering patient groups in sequential electronic healthcare data using unsupervised representation learning.
BMC Med Inform Decis Mak
January 2025
Great Ormond Street Institute of Child Health, University College London, London, UK.
Introduction: Unsupervised feature learning methods inspired by natural language processing (NLP) models are capable of constructing patient-specific features from longitudinal Electronic Health Records (EHR).
Design: We applied document embedding algorithms to real-world paediatric intensive care (PICU) EHR data to extract patient-specific features from 1853 patients' PICU journeys using 647 unique lab tests and medication events. We evaluated the clinical utility of the patient features via a K-means clustering analysis.
Metabolic profiles and potential antioxidant mechanisms of hawk tea.
Sci Rep
January 2025
Department of Food Science and Engineering, Moutai Institute, Renhuai, 564502, People's Republic of China.
Hawk tea has received increasing attention for its unique flavor and potential health benefits, with antioxidant function being one of its significant bioactivities. However, the metabolic profiles, potential antioxidant components, and action mechanisms of different types of hawk tea are still unclear. In this study, the chemical components of five hawk teas were determined using untargeted metabolomics.
View Article and Find Full Text PDFEnantioselective synthesis of 2-substituted bicyclo[1.1.1]pentanes via sequential asymmetric imine addition of bicyclo[1.1.0]butanes and skeletal editing.
Nat Chem
January 2025
Shenzhen Grubbs Institute, Department of Chemistry, Southern University of Science and Technology, Shenzhen, China.
The substitution of an aromatic ring with a C(sp)-rich bicyclic hydrocarbon, known as bioisosteric replacement, plays a crucial role in modern drug discovery. Substituted bicyclo[1.1.
View Article and Find Full Text PDFRaptin, a sleep-induced hypothalamic hormone, suppresses appetite and obesity.
Cell Res
January 2025
Department of Endocrinology, Endocrinology Research Center, Xiangya Hospital of Central South University, Changsha, Hunan, China.
Sleep deficiency is associated with obesity, but the mechanisms underlying this connection remain unclear. Here, we identify a sleep-inducible hypothalamic protein hormone in humans and mice that suppresses obesity. This hormone is cleaved from reticulocalbin-2 (RCN2), and we name it Raptin.
View Article and Find Full Text PDFEfficacy of a multicomponent nature-based intervention on well-being and environmental engagement: A randomized clinical trial.
Environ Int
January 2025
Einstein Excellence Office, Hospital Israelita Albert Einstein - Paulista Av, 2300 - Consolação. Zip code: 01310-300 - São Paulo, Brazil. Electronic address:
Background: Nature-based interventions (NBIs) benefit human well-being, but clinical trials comparing different NBIs in various natural environments are scarce.
Objective: To evaluate the efficacy of a multicomponent nature-based intervention (MNBI) in comparison to control group (classical forest bathing).
Primary Outcome: well-being; Secondary outcomes: vitality, happiness, connection, and engagement with nature across urban, peri-urban, and rural areas.
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