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Platelets as crucial players in the dynamic interplay of inflammation, immunity, and cancer: unveiling new strategies for cancer prevention.
Front Pharmacol
December 2024
Systems Pharmacology and Translational Therapeutics Laboratory, The Center for Advanced Studies and Technology (CAST), "G. d'Annunzio" University, Chieti, Italy.
Inflammation plays a critical role in the pathogenesis of various diseases by promoting the acquisition of new functional traits by different cell types. Shared risk factors between cardiovascular disease and cancer, including smoking, obesity, diabetes, high-fat diet, low physical activity, and alcohol consumption, contribute to inflammation linked to platelet activation. Platelets contribute to an inflammatory state by activating various normal cells, such as fibroblasts, immune cells, and vascular cells.
View Article and Find Full Text PDFNeuropharmacological potential of Mimosa tenuiflora in adult zebrafish: An integrated approach to GABAergic and serotonergic neuromodulation.
Behav Brain Res
January 2025
Experimental Biology Center, University of Fortaleza, Av. Washington Soares, 1321, Fortaleza, Ceará, Brazil; Laboratory of Bioprospection of Natural Products and Biotechnology, Department of Chemistry, CECITEC/UECE - Center for Education, Science and Technology of the Inhamuns Region. R. Seis, 15 - Bezerra de Sousa, Tauá, Ceará, Brazil. Electronic address:
Mimosa tenuiflora ("jurema-preta") is traditionally used in folk medicine for various diseases. The study investigated the neuropharmacological potential of Mimosa tenuiflora bark fraction (FATEM) in adult zebrafish. This included the acute toxicity (LC50) of FATEM (0.
View Article and Find Full Text PDFGrouping of chemicals for safety assessment: the importance of toxicokinetic properties of salicylate esters.
Arch Toxicol
January 2025
Cosmetics Europe, Brussels, Belgium.
Grouping of chemicals has been proposed as a strategy to speed up the screening and identification of potential substances of concern among the broad chemical universe under REACH. Such grouping is usually based on shared structural features and should only be used for the prioritization objectives. However, additional considerations (as well as structural similarity) are needed, e.
View Article and Find Full Text PDFDown the "Black Hole" of Sexual Violence in the Brussels Nightlife: A Qualitative Exploration of Social Media Testimonials.
Violence Against Women
January 2025
Research Center of Gender, Diversity and Intersectionality (RHEA), Vrije Universiteit Brussel (VUB), Brussels, Belgium.
The Instagram account (@Balance_ton_bar) highlighted the issue of sexual violence in Brussels nightlife sharing testimonials from victim-survivors. Set up in response to reports of drug-facilitated sexual assault at nightlife establishments, the account aimed to raise awareness and hold establishments accountable. This study examines these testimonials to explore how violence was perpetrated-through chemical drugging, alcohol use, isolation, and social power-the socio-emotional consequences for victim-survivors, and their journeys in seeking support.
View Article and Find Full Text PDFExploration of bioactive molecules from Sesbania grandiflora (L.): identification of squalene as an effective compound against the two-spotted spider mite, Tetranychus urticae Koch, through molecular docking.
Exp Appl Acarol
December 2024
Department of Agricultural Entomology, Tamil Nadu Agricultural University, Coimbatore, Tamil Nadu, 641003, India.
Two-spotted spider mite (TSSM), Tetranychus urticae Koch is a devastating polyphagous mite causing considerable economic loss. Acaricides are showered in crops to manage this pest. The pest is known for developing resistance to several classical acaricides.
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