The potential development of heat-related mortality in the 21th century for Vienna (Austria) was assessed by the use of two regional climate models based on the IPCC emissions scenarios A1B and B1. Heat stress was described with the human-biometeorological index PET (Physiologically Equivalent Temperature). Based on the relation between heat stress and mortality in 1970-2007, we developed two approaches to estimate the increases with and without long-term adaptation. Until 2011-2040 no significant changes will take place compared to 1970-2000, but in the following decades heat-related mortality could increase up to 129% until the end of the century, if no adaptation takes place. The strongest increase occurred due to extreme heat stress (PET >or= 41 degrees C). With long-term adaptation the increase is less pronounced, but still notable. This encourages the requirement for additional adaptation measurements.
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http://dx.doi.org/10.3390/ijerph7072965 | DOI Listing |
Front Cell Dev Biol
January 2025
Department of Cell and Cancer Biology, College of Medicine and Life Sciences, The University of Toledo, Toledo, OH, United States.
Heat Shock Factor 1 (HSF1) is a major transcriptional factor regulating the heat shock response and has become a potential target for overcoming cancer chemoresistance. This review comprehensively examines HSF1's role in chemoresistance and its potential as a therapeutic target in cancer. We explore the complex, intricate mechanism that regulates the activation of HSF1, HSF1's function in promoting resistance to chemotherapy, and the strategies used to manipulate HSF1 for therapeutic benefit.
View Article and Find Full Text PDFMol Breed
February 2025
National Nanfan Research Institute (Sanya), Chinese Academy of Agricultural Sciences, Sanya, 572024 China.
Unlabelled: Chickpea (. L) holds the esteemed position of being the second most cultivated and consumed legume crop globally. Nevertheless, both biotic and abiotic constraints limit chickpea production.
View Article and Find Full Text PDFInt J Physiol Pathophysiol Pharmacol
December 2024
Gene Expression and Signaling Lab, Department of Zoology, Mahatma Gandhi Central University Motihari Motihari, Bihar 845401, India.
Objective: The Heat Shock Protein 70 (HSP70) family is a highly conserved group of molecular chaperones essential for maintaining cellular homeostasis. These proteins are necessary for protein folding, assembly, and degradation and involve cell recovery from stress conditions. HSP70 proteins are upregulated in response to heat shock, oxidative stress, and pathogenic infections.
View Article and Find Full Text PDFIran J Basic Med Sci
January 2025
Artemia & Aquaculture Research Institute, Urmia University, Urmia, Iran.
Objectives: Nonalcoholic fatty liver disease (NAFLD) is known to disrupt testicular anti-oxidant capacity, leading to oxidative stress (OS) that can negatively affect male fertility by damaging sperm DNA. Heat shock proteins (HSP70 and HSP90), in association with transitional proteins (TP1 and TP2), play crucial roles in protecting sperm DNA integrity in oxidative conditions. Whiteleg shrimp protein hydrolysates (HPs) exhibit anti-oxidant properties, prompting this study to explore the potential of HPs in ameliorating NAFLD-induced testicular damage.
View Article and Find Full Text PDFBMC Oral Health
January 2025
Department of Conservative Dentistry, School of Dentistry, Dental Research Institute, Dental and Life Science Institute, Pusan National University, Yangsan, Korea.
Background: This study compared the torsional resistance, bending stiffness, and cyclic fatigue resistances of different heat-treated NiTi files for minimally invasive instrumentation.
Methods: TruNatomy (TN) and EndoRoad (ER) file systems were compared with ProTaper Gold (PG). Torsional load, distortion angle, and bending stiffness were assessed using a custom device AEndoS, and toughness was calculated using the torsional data.
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