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Causal relationship between gut microbiota and lung squamous cell carcinoma: a bidirectional two-sample Mendelian randomization study.
Postgrad Med J
December 2024
Department of Thoracic Surgery, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Chaoyang District, Panjiayuan, Nanli 17, Beijing 100021, People's Republic of China.
Purpose: This study aims to explore the potential causal relationship between gut microbiota and lung squamous cell carcinoma (LUSC).
Methods: A bidirectional two-sample Mendelian randomization analysis was conducted using genome-wide association study (GWAS) data from gut microbiota and LUSC. Gut microbiota served as the exposure factor, with instrumental variables selected from a GWAS involving 18 340 participants.
Functional Modulation of Gut Microbiota and Blood Parameters in Diabetic Rats Following Dietary Intervention with Free or Immobilized SK Cells on Pistachio Nuts.
Nutrients
December 2024
Laboratory of Applied Microbiology and Biotechnology, Department of Molecular Biology and Genetics, Democritus University of Thrace, 68100 Alexandroupolis, Greece.
Background/objectives: The gut microbiota is linked to the pathogenesis of type 1 diabetes mellitus (T1DM), while supplementation with probiotics may result in positive alterations in the composition of the gut microbiome. This research aimed to map the changes in the gut microbiome and blood markers of streptozotocin-induced diabetic rats after a dietary intervention with free or immobilized cells of the presumptive probiotic SK on pistachio nuts.
Methods: Twenty-four male Wistar rats were studied and divided into four groups (healthy or diabetic) which received the free or the immobilized .
The Key Nutrients in the Mediterranean Diet and Their Effects in Inflammatory Bowel Disease: A Narrative Review.
Nutrients
December 2024
CEMAD Translational Research Laboratories, Dipartimento di Scienze Mediche e Chirurgiche, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, 00168 Rome, Italy.
The gut microbiome, a collection of gut microorganisms, is crucial in the development and progression of inflammatory bowel diseases (IBD). Therefore, diet and dietary interventions are promising strategies to shape the gut microbiota for IBD management. Of all the diets studied in the IBD field, the Mediterranean diet has the least restrictive nature, promoting long-term adherence.
View Article and Find Full Text PDFPublic acceptance of microbiome management strategy in dairy calves: a European survey on colostrum, probiotic provision and prolonged cow-calf contact.
Animal
November 2024
Natural Resources Institute Finland (Luke), Business Economics, Latokartanonkaari 9, FI-00790, Helsinki, Finland.
The microbiome plays a crucial role in the calves' early stages of life. Several management practices can be considered to enhance the development and composition of the microbiome in calves. However, their social acceptance is largely unknown.
View Article and Find Full Text PDFAntibiotic-perturbed microbiota and the role of probiotics.
Nat Rev Gastroenterol Hepatol
December 2024
International Scientific Association for Probiotics and Prebiotics, Consulting Scientific Advisor, Centennial, CO, USA.
Article Synopsis
- * Clinical studies show probiotics might help reduce side effects like diarrhea from Clostridioides difficile, yet there's no direct evidence connecting these outcomes to microbiota protection.
- * The review discusses the complexities of studying microbiota restoration, including the challenges of defining a "normal" microbiota, varying measurement methods, and individual differences, while suggesting future research directions.
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