AI Article Synopsis
- A new type of macrolide derivatives with 4''-O-mono- or disaccharides was created using glycosyl trichloroacetimidates for glycosylation.
- Tests were conducted to evaluate the antibacterial effectiveness of these derivatives against both susceptible and resistant bacterial pathogens.
- This research aims to enhance our understanding of how these modified macrolides interact with bacterial ribosomes, potentially leading to better antibacterial treatments.
Article Abstract
A series of novel derivatives of macrolide with 4''-O-mono- or disaccharides were synthesized. The corresponding glycosyl trichloroacetimidates were used as the donors in the glycosylations. The in vitro antibacterial activities of 7a-f and 13-16 against a panel of susceptible and resistant pathogens were tested. The modification of 4''-O-mono- or disaccharides may lead to the understanding of interaction of the macrolide and the bacterial ribosome.
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| http://dx.doi.org/10.1016/j.bmcl.2010.07.072 | DOI Listing |
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