AI Article Synopsis
- A new nanofluidic technology was developed for separating and measuring nanoparticles on a chip through an engineered channel with a unique staircase-like depth profile.
- The method utilized multiple stepped reductions in channel depth to achieve size exclusion of a mixed population of nanoparticles.
- Epifluorescence microscopy played a key role in visualizing the size exclusion, allowing for the measurement of nanoparticle size distributions and confirming the effectiveness of the separation process.
Article Abstract
A nanofluidic technology for the on-chip size separation and metrology of nanoparticles is demonstrated. A nanofluidic channel was engineered with a depth profile approximated by a staircase function. Numerous stepped reductions in channel depth were used to separate a bimodal mixture of nanoparticles by nanofluidic size exclusion. Epifluorescence microscopy was used to map the size exclusion positions of individual nanoparticles to corresponding channel depths, enabling measurement of the nanoparticle size distributions and validation of the size separation mechanism.
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| http://dx.doi.org/10.1039/c0lc00029a | DOI Listing |
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