Background: The prethrombotic state can be observed in advanced lung cancer patients. The aim of this study is to investigate the relationship between coagulation and fibrinolysis marks on pathophysiological characteristics and prognosis in patients with lung cancer.
Methods: The coagulation and fibgrinolysis marks were detected in sixty patients with lung cancer and twenty normal controls.
Results: The D-dimer, fibrinogen degradation products, plasma fibrinogen were significantly higher than those of normal controls. The plasma antithrombin III was significantly lower than those of normal controls. All marks in patients with lung cancer were not related to age, sex, histological classification, the size of the primary tumors, P-TNM stages, distant metastasis. The plasma levels of D-dimer and fibrinogen in patients with lung cancer were negatively correlated to survival.
Conclusions: The patients with lung cancer have abnormal coagulation and fibrinolysis state, these contribute to hypercoagulability state and thrombi. The plasma levels of D-dimer and fibrinogen in patients with lung cancer were correlated with prognosis. The anticoagulability medicine treatment are benefit for the patients with lung cancer.
Download full-text PDF |
Source |
---|---|
http://dx.doi.org/10.3779/j.issn.1009-3419.2009.01.007 | DOI Listing |
Diagn Interv Radiol
January 2025
Huadong Hospital, Fudan University, Department of Thoracic Surgery, Shanghai, China.
Purpose: Patients with advanced non-small cell lung cancer (NSCLC) have varying responses to immunotherapy, but there are no reliable, accepted biomarkers to accurately predict its therapeutic efficacy. The present study aimed to construct individualized models through automatic machine learning (autoML) to predict the efficacy of immunotherapy in patients with inoperable advanced NSCLC.
Methods: A total of 63 eligible participants were included and randomized into training and validation groups.
J Cachexia Sarcopenia Muscle
February 2025
Center for Health Information Partnerships, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA.
Background: Cancer-associated cachexia can inhibit immune checkpoint inhibitor (ICI) therapy efficacy. Cachexia's effect on ICI therapy has not been studied in large cohorts of cancer patients aside from lung cancer. We studied associations between real-world routinely collected clinical cachexia markers and disability-free, hospitalization-free and overall survival of cancer patients.
View Article and Find Full Text PDFClin Cardiol
January 2025
National Heart and Lung Institute, Imperial College London, London, UK.
Background: Parkinson disease (PD) and cardiovascular diseases (CVD) present significant health burdens, particularly among older adults. Patients with PD have an elevated risk of CVD-related mortality. Analyzing mortality trends in this population may help guide focused interventions.
View Article and Find Full Text PDFJ Am Heart Assoc
January 2025
Department of Cardiovascular Surgery, Beijing Anzhen Hospital, Capital Medical University, and The Key Laboratory of Cardiovascular Remodeling-related Diseases, Ministry of Education, and Beijing Institute of Heart Lung and Blood Vessel Disease Beijing China.
Background: Acute type A aortic dissection (AAD) and acute type A intramural hematoma (AIMH) are life-threatening conditions with high mortality rates, and prognostic indicators are critical for guiding urgent treatment decisions. We assessed the prognostic significance of admission D-dimer levels in patients with AAD and AIMH.
Methods And Results: The prospective, multicenter, observational study in China recruited participants from 2013 to 2019.
Exp Physiol
January 2025
Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
There is limited knowledge on diffusing capacity in scoliosis patients. It remains to be determined if impaired pulmonary diffusing capacity is mostly influenced by reduced alveolar-capillary membrane diffusing capacity (D), reduced pulmonary capillary blood volume (V) or both. This study aims to report findings from dual test gas pulmonary diffusing capacity for carbon monoxide and nitric oxide (D) with quantification of pulmonary diffusing capacity for carbon monoxide corrected for haemoglobin with a five s breath-hold (D) and nitric oxide with a five s breath-hold (D), D and V.
View Article and Find Full Text PDFEnter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!