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Role of desmosomal components in the initiation and metastasis of oral cancer-A review.
J Oral Maxillofac Pathol
September 2023
Department of Periodontics, GITAM Dental College and Hospital, Visakhapatnam, Andhra Pradesh, India.
Desmosomes are composed of a number of proteins, including cadherins, armadillo proteins and plakoplilins, which are responsible for mediating cell-cell adhesion. Cadherins are transmembrane proteins that bind to each other on adjacent cells, forming a strong adhesive bond between the cells. In normal tissues, desmosomes help to maintain the structural integrity of the tissue by holding the cells together.
View Article and Find Full Text PDFPeriodontitis and oral Cancer-A striking link.
Oral Oncol
July 2020
Department of Head and Neck Onclogy, Health Care Global Cancer Center, India.
Oral squamous cell carcinoma (OSCC) has become a major public health problem in the worldwide for its increasing incidence and mortality, especially in younger trends. Risk factors for OSCC apart from alcohol and tobacco use, include poor oral hygiene, inflammation caused by inadequately fitting dentures and other rough teeth surfaces, poor nutrition and some chronic infections caused by fungi, bacteria or viruses. Several studies have also found that the risk of developing OSCC may increase with periodontal disease (PD).
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