Purpose: To analyse trends in sales of potentially inappropriate psychotropic substances (PIPS) in relation to drugs recommended by Drug and Therapeutics Committees (DTC drugs) among 75-year olds and among individuals born 1925 in Sweden.
Methods: Trends in sales of PIPS and DTC drugs among 75-year olds and among individuals born 1925 in Sweden during 2000-2008 were analysed with linear regression models. Sales were measured as defined daily doses per 1000 inhabitants and day. PIPS were defined according to a proposal from the Swedish National Board of Health and Welfare. The selection of DTC drugs was based on a review of recommendations from local DTCs.
Results: Among 75-year olds, PIPS sales decreased 38% and DTC drugs sales increased 31% from 2000 to 2008. The hypnotic PIPS decreased 45%, while the DTC hypnotics increased 36%. The total sales of PIPS to individuals born in 1925 decreased 12% from 2000 to 2008. The DTC drugs increased 115%. Sales of hypnotic PIPS decreased 12%, and the hypnotic DTC drugs increased 120%.
Conclusions: The findings indicate a trend towards the utilization of DTC drugs rather than PIPS.
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http://dx.doi.org/10.1002/pds.1967 | DOI Listing |
CNS Drugs
January 2025
School of Medicine and Dentistry, Gold Coast Campus, Griffith University, Southport, QLD, 4222, Australia.
Background: Epstein-Barr virus (EBV) is implicated as a necessary factor in the development of multiple sclerosis (MS) and may also be a driver of disease activity. Although it is not clear whether ongoing viral replication is the driver for MS pathology, MS researchers have considered the prospect of using drugs with potential efficacy against EBV in the treatment of MS. We have undertaken scientific and lived experience expert panel reviews to shortlist existing licensed therapies that could be used in later-stage clinical trials in MS.
View Article and Find Full Text PDFLancet Reg Health Eur
February 2025
Bristol Medical School, University of Bristol, Bristol, UK.
Background: England aims to reach the World Health Organization (WHO) elimination target of decreasing HCV incidence among people who inject drugs (PWID) to <2 per 100 person-years (/100pyrs) by 2030. We assessed what testing and treatment strategies will achieve this target and whether they are cost-effective.
Methods: A dynamic deterministic HCV transmission model among PWID was developed for four England regions, utilising data on the scale-up of HCV treatment among PWID in prisons, drug treatment centres (DTC, where opioid agonist therapy is provided), and any other setting (e.
Ther Innov Regul Sci
December 2024
RTI International, Research Triangle Park, NC, 27709, USA.
Background: Prescription drugs may be indicated to treat more than one medical condition, and companies may promote more than one indication in the same direct-to-consumer (DTC) ad. This study examined how presenting multiple prescription drug indications in one DTC television ad affects consumers' processing of drug information.
Methods: We conducted two studies with adults diagnosed with diabetes (Study 1, N = 408) or rheumatoid arthritis (Study 2, N = 411).
Patient Educ Couns
March 2025
Center for Drug Evaluation and Research, US. Food and Drug Administration, Silver Spring, MD, USA.
Objective: The rise in direct-to-consumer (DTC) ads for cancer drugs, which often have complex indications, raises concerns about consumer misunderstanding. A drug's indication must clearly convey its condition(s) of use, which may include elements such as the approved patient population, second-line treatment status, and whether it is adjunctive or concomitant therapy. The study examines whether the modality used to communicate the drug's indication in DTC television ads affects consumers' recognition, recall, and comprehension.
View Article and Find Full Text PDFEndocrinology
November 2024
Department of Nuclear Medicine, West China Hospital, Sichuan University, Chengdu 610000, China.
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