AI Article Synopsis
- Neonatal status epilepticus (SE) negatively impacts the prefrontal cortex and thalamus, areas important for social interactions.
- An experiment using the "intruder-resident" paradigm on 9-day-old Wistar rats showed that neonatal SE leads to social deficits in male rats and decreased movement in both genders, while also increasing self-grooming behavior in females.
- Further research is needed to determine if these social behavior impairments persist throughout the rats' lives.
Article Abstract
Neonatal status epilepticus (SE) disrupts prefrontal cortex and thalamus, brain regions related to social play. Juvenile play was evaluated using the "intruder-resident" paradigm following SE in 9-day-old Wistar pups of both genders. Quite interestingly, we demonstrated for the first time that neonatal SE produces social impairment in male rats, reduces locomotor activity in both genders and enhances self-grooming in female. Additional studies are necessary to clarify if these effects can impair social behavior across the life span.
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| http://dx.doi.org/10.1007/s00702-010-0460-1 | DOI Listing |
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