AI Article Synopsis
- A 37-year-old woman with a history of psychosis was hospitalized in 2007, presenting symptoms of polyarthritis and severe skin lesions causing necrosis and ulceration on her limbs.
- She was diagnosed with systemic lupus erythematosus (SLE) and tested positive for lupus anticoagulant, indicating secondary antiphospholipid syndrome (APS).
- The case illustrates that severe skin necrosis can be an initial sign of secondary APS and that her condition improved with a combined treatment of anticoagulation and immunomodulation.
Article Abstract
Diffuse necrotic-hemorrhagic lesions limited to the skin in secondary antiphospholipid antibody syndrome (APS) to systemic lupus erythematosus (SLE) are not frequent. We report the case of a white woman, 37 years of age, hospitalized in September 2007 with a history of psychosis of several years' duration, presenting with polyarthritis and erythematous, maculopapular, bullous skin lesions on the upper and lower limbs, rapidly followed by extensive necrosis and skin ulceration on all four limbs who was diagnosed with SLE and positive lupus anticoagulant. The investigators highlight the occurrence of skin necrosis of catastrophic characteristics, as a possible initial manifestation of secondary APS without systemic vascular involvement that evolved satisfactorily with a combination treatment of anticoagulation and immunomodulation.
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