An in vitro assay for the simultaneous measurement of lipid peroxidation (LPO) and bilirubin degradation (BRD) activities in rat liver microsomes has been developed; a good correlation between the 2 activities was observed (r = 0.78). In the Gunn rat a lipid free diet caused an increase in plasma bilirubin (62.4 +/- 25.8%, n = 6) and a concomitant decrease in both hepatic microsomal LPO and BRD to zero. In contrast, on a 25% lipid diet there was a decrease in plasma bilirubin (46.1 +/- 3.6%; n = 8) associated with an increase in LPO (1.26 +/- 0.11 nmol/min/mg protein, and BRD (0.21 +/- 0.6 nmol/min/mg protein). Therefore, in the absence of bilirubin glucuronidation, dietary modulation of plasma bilirubin and lipid peroxidation appear to be closely associated.
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