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Protective effect of valerian extract capsule (VEC) on ethanol- and indomethacin-induced gastric mucosa injury and ameliorative effect of VEC on gastrointestinal motility disorder.
Pharm Biol
December 2022
Science and Technology Innovation Center, Guangzhou University of Chinese Medicine, Guangzhou, China.
Context: Valerian extract capsule (VEC) is an effective Chinese patent medicine used for gastrointestinal (GI) diseases.
Objective: To investigate the detailed pharmacological activity for VEC clinical effects in GI diseases.
Materials And Methods: Sprague-Dawley rats were divided into six groups: control, model, and drug-treated (VEC-L, VEC-M, VEC-H, and teprenone).
In vitro effect of valepotriates isolated from Valeriana glechomifolia on rat P-type ATPases.
Planta Med
October 2011
Laboratório de Farmacologia Bioquímica e Molecular, Instituto de Ciências Biomédicas, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil.
Valepotriates are iridoids found in variable amounts in Valerianaceae and might be among the bioactive compounds which confer anxiolytic properties to the Valeriana species. On the other hand, unspecific cytotoxicity has also been described. Presently, however, no particular molecular target has been defined for these compounds.
View Article and Find Full Text PDFVasorelaxant effect of Valeriana edulis ssp. procera (Valerianaceae) and its mode of action as calcium channel blocker.
J Pharm Pharmacol
September 2010
Facultad de Farmacia, Universidad Autónoma del Estado de Morelos, Avenida Universidad 1001, Col. Chamilpa, 62209, Cuernavaca, Morelos, México.
Objectives: The aim was to evaluate the relaxant effect of extracts from Valeriana edulis and determine the possible mechanism of action of the hexanic extract as vasorelaxant agent.
Methods: Extracts from rhizomes obtained by maceration (hexanic (HEVe), dichloromethanic (DEVe), methanolic (MEVe) and hydroalcoholic (HAEVe) (3.03-500 microg/ml)) were evaluated on aortic rat rings with and without endothelium.
Relaxing effects of Valeriana officinalis extracts on isolated human non-pregnant uterine muscle.
J Pharm Pharmacol
February 2009
Pharmaco-Biological Department, School of Pharmacy, University of Messina, Messina, Italy.
Objectives: This study investigated the relaxing effects of Valeriana officinalis L. (Valerianaceae) on human uterine muscle. The major uses of this species in Europe are as a sedative and an anxiolytic; it is also used as a spasmolytic to treat gastrointestinal spasm.
View Article and Find Full Text PDFHigh-yield production of valepotriates by hairy root cultures of Valeriana officnalis L. var. sambucifolia Mikan.
Plant Cell Rep
July 1992
Department of Pharmacognosy, University of Geneva, Sciences II, 30, Quai E.-Ansermet, CH-1211, 4, Geneva, Switzerland.
Hairy root cultures of Valeriana officinalis var. sambucifolia were established by infection of sterile plantlets with Agrobacterium rhizogenes strain R1601 The transformed roots were grown in 10 different, hormone-free liquid media and the isovaltrate, valtrate, didrovaltrate, isovaleroxyhydroxydidrovaltrate content was quantified by HPLC. Valepotriates were entirely retained inside the root tissues.
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