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Anaphylactoid reaction to adenosine.

Prehosp Disaster Med

September 1996

Department of Medicine, Michigan State University, College of Human Medicine, Lansing, USA.

Adenosine (Adenocard) is an endogenous purine nucleoside that has been approved recently for intravenous treatment of paroxysmal supraventricular tachycardia. With a serum half-life of 10 seconds, reported side effects including facial flushing, dyspnea, and chest pressure are common, but very transient. An elderly woman who received adenosine for paroxysmal supraventricular tachycardia had a prolonged anaphylactoid reaction that required pharmacological treatment.

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Adenosine (Adenocard) has a potent but very transient negative dromotropic effect on atrioventricular (A-V) nodal conduction. By slowing A-V nodal conduction, adenosine may interrupt a re-entry pathway causing paroxysmal supraventricular tachycardia or facilitate the diagnosis of other supraventricular tachycardia (SVT) by exposing the underlying atrial activity. We report 15 postoperative cases in which adenosine was used to clarify the diagnosis of postoperative SVT, and allowed the appropriate postoperative care.

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Adenosine (Adenocard) is a unique new agent for the acute treatment of paroxysmal supraventricular tachycardia (PSVT). Administered by intravenous bolus, it has an onset and duration measured in seconds and greater than 90% efficacy. Its primary effect is to slow atrioventricular nodal conduction, thus converting reentrant forms of PSVT to normal sinus rhythm.

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Supraventricular tachycardia. Changes in management.

Postgrad Med

August 1991

Department of Internal Medicine, University of Arizona Health Sciences Center, Tucson 85724.

The various forms of supraventricular tachycardia can be differentiated by careful review of a patient's electrocardiogram. If reentrant tachycardia involves the atrioventricular node, intravenous adenosine (Adenocard) provides a rapid means of converting the tachycardia to sinus rhythm. Adverse effects of adenosine, though common, are mild and of brief duration.

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