Internationally, Norway receives positive attention mainly in the context of Winter Olympics or peace initiatives. However, an Associated Press article recently suggested that the Norwegian health care system had "found the Solution to Killer Superbug". Furthermore, Norway was proclaimed "The Most Infection Free Country in the World". What my be the reality behind such headlines, and how shall we as a nation maintain a favourable situation? Physicians in Scandinavian countries and the Netherlands have a long tradition for modest prescription of antibiotics, and are trained to use agents with a narrow antimicrobial spectre whenever possible. This is probably the main reason why these countries have had less antibiotic resistance than others. The number of antibiotics marketed in a country correlates positively with total drug consumption. Until 1992, Norwegian authorities could reject marketing of new compounds if national experts found no medical need for them. The foresight of senior colleagues has led to the number of marketed antibiotics in Norway, even today, being 10-fold lower than in some other European countries. The national surveillance programme, NORM, reports antimicrobial resistance in human pathogens on an annual basis. For example, national levels of MRSA and ESBL-producing Enterobacteriaceae are still very low whereas ampicillin and ciprofloxacin resistance in E coli and high- level gentamicin resistance in enterococci cause some concern. Norway has well-established epidemiological surveillance systems in the fields of microbiology and infectious diseases. Nevertheless, more knowledge is needed on how antibiotics are used in hospitals. Two national strategic plans (since 2003) have emphasized the explicit importance of antibiotic surveillance to counteract future antibiotic resistance problems. To fulfil national ambitions, there is an urgent need for economic grants to this field; the human resources are there and as eager to start as Olympic performers!
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http://dx.doi.org/10.4045/tidsskr.10.0356 | DOI Listing |
Vet Res Commun
December 2024
Institute of Biochemistry and Biotechnology, University of Veterinary and Animal Sciences, Lahore, 54000, Pakistan.
Camel mastitis especially caused by Staphylococcus aureus (S. aureus), is a major risk to animal health and milk production. The current investigation evaluated the antibiotic susceptibility and virulence factors of S.
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December 2024
Department of Microbiology and Parasitology, Faculty of Science, University of Buea, Box 63, Buea, Cameroon.
Objectives: Methicillin-resistant Staphylococcus aureus (MRSA) is a zoonotic pathogen that poses a serious threat to veterinary and public health worldwide. We investigated mastitis milk samples for contamination with MRSA and also characterized the MRSA isolates by investigating antimicrobial resistance and virulence factors.
Result: We confirmed MRSA in 69 of 201 (34.
BMC Infect Dis
December 2024
Xi'an Chest Hospital, Xi'an, Shaanxi Province, China.
Objectives: This study evaluates the effectiveness of nanopore sequencing for accurate detection of Mycobacterium tuberculosis pathogens and drug resistance mutations in clinical specimens.
Methods: A retrospective analysis of 2,421 specimens from suspected tuberculosis patients admitted to Xi'an Chest Hospital from 2022 to 2023 was conducted, with 131 specimens undergoing via real-time, fluorescence-based quantitative Polymerase Chain Reaction (qPCR), simultaneous amplification and testing RNA (RNA), Mycobacterium culture, Mycobacterium smear, and nanopore sequencing. Employing clinical tuberculosis diagnoses as the gold standard, sensitivity, specificity, positive predictive value, negative predictive value, concordance rate, and Kappa coefficient were measured for the five detection techniques.
BMC Infect Dis
December 2024
Department of Infectious Diseases and Hospital Epidemiology, University Hospital Zurich, University of Zürich, Zurich, 8097, Switzerland.
Introduction: The ability to detect pathogenic bacteria before the onsets of severe respiratory symptoms and to differentiate bacterial infection allows to improve patient-tailored treatment leading to a significant reduction in illness severity, comorbidity as well as antibiotic resistance. As such, this study refines the application of the non-invasive Secondary Electrospray Ionization-High Resolution Mass Spectrometry (SESI-HRMS) methodology for real-time and early detection of human respiratory bacterial pathogens in the respiratory tract of a mouse infection model.
Methods: A real-time analysis of changes in volatile metabolites excreted by mice undergoing a lung infection by Staphylococcus aureus or Streptococcus pneumoniae were evaluated using a SESI-HRMS instrument.
BMC Pediatr
December 2024
Research Product Department, R&D Center, Glac Biotech Co., Ltd, Tainan City, Taiwan.
Background: Breast milk is a natural treasure for infants, and its microbiota contains a rich array of bacterial species. When breastfeeding is not possible, infant formula with probiotics can be used as a sole source or as a breast milk supplement. The main aim of this study was to evaluate the growth outcomes and tolerance of infants consuming an infant formula containing Bifidobacterium animalis ssp.
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