Interaction of Saccharomyces boulardii with intestinal brush border membranes: key to probiotic effects?

J Pediatr Gastroenterol Nutr

Laboratory of Pediatric Gastroenterology and Nutrition, Department of Pediatric Research, University of Louvain, Brussels, Belgium.

Published: October 2010

The probiotic Saccharomyces boulardii exerts beneficial effects in humans, which include trophic effects, anti-inflammatory effects, antisecretory effects, inhibition of toxins, immunostimulatory effects, and resistance to bacterial overgrowth. This short communication discusses the interactions of the probiotic with brush border membrane (BBM) constituents because most of these effects are BBM mediated. The use of bacterial and yeast probiotics has increased dramatically in more and more clinical states, but their exact mechanisms of action remain largely unknown. The present communication focuses on the interactions of a confirmed yeast probiotic (S boulardii) on the constituents of BBMs.

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http://dx.doi.org/10.1097/MPG.0b013e3181e23271DOI Listing

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