AI Article Synopsis
- The study investigates how maternal isolation stress affects seizure susceptibility in young rats and explores potential mechanisms.
- Young rats subjected to 3 hours of daily isolation showed reduced weight, lower seizure thresholds, and more severe seizures compared to normal controls, illustrating a significant impact of prolonged stress.
- The findings indicate that decreased expression of the GABA(A) receptor α₁ in the hippocampus may link early stress to increased risk of epilepsy.
Article Abstract
Objective: To study the effect of maternal isolation stress on the epilepsy susceptibility in young rats and the possible mechanism.
Methods: Sixty Sprague-Dawley young rats were randomly divided into a normal control and two maternal isolation groups that were subjected to maternal isolation for 15 min or 3 hrs daily on postnatal days 2-17. On postnatal day 18, an amygdala kindling test was performed to induce seizures. The expression of GABA(A) receptor α₁ in the hippocampus was determined by immunohistochemisty.
Results: The weights were reduced, the threshold of amygdala kindling and the stimulation number for full kindling decreased significantly, and seizures were more severe in the maternal isolation 3 hrs group compared with the normal control group. The expression of GABA(A) receptor alpha(1) in the hippocampus CA1 area in the maternal isolation 3 hrs group decreased significantly compared with that in the normal groups. There were no significant differences in the aspects above mentioned between the maternal isolation 15 min and normal control groups.
Conclusions: The stress of early daily maternal isolation for 3 hrs may affect adversely brain development and increase epilepsy susceptibility in young rats. The decreased expression of GABA(A) receptor α₁ in the hippocampus may contribute to the potential mechanism.
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