Lucknolides A and B, tricyclic ketal-lactone metabolites from a terrestrial Streptomyces sp.

Org Lett

Institute of Organic and Biomolecular Chemistry, University of Göttingen, Tammannstrasse 2, D-37077 Göttingen, Germany.

Published: September 2010

AI Article Synopsis

  • Two new tricyclic highly functionalized ketal-lactone metabolites, lucknolide A (1) and lucknolide B (2), were discovered during a micro-organism screening for secondary metabolites.
  • The compounds were thoroughly analyzed using NMR (Nuclear Magnetic Resonance) and mass spectrometry techniques for characterization.
  • Additionally, single-crystal X-ray diffraction was utilized to study the structure and determine the absolute configuration of lucknolide A (1).

Article Abstract

In a screening of micro-organisms for new secondary metabolites, two unprecedented tricyclic highly functionalized ketal-lactone metabolites, named lucknolide A (1) and lucknolide B (2), have been isolated, and the compounds were characterized by extensive NMR and mass spectroscopic studies. Single-crystal X-ray diffraction experiments on 1 and 2 were performed, and the absolute configuration of 1 was determined.

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Source
http://dx.doi.org/10.1021/ol1014703DOI Listing

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