The radiopharmaceutical strontium chloride ((89)Sr) has been released as a new means of pain relief for painful bone metastasis in cancer patients. Because (89)Sr is a pure beta-emitting nuclide, it was considered difficult to know its distribution in the body from outside. Imaging with a gamma camera using bremsstrahlung radiation has been reported as one method, but there has been little detailed basic examination. We examined the optimal energy window and collimator when imaging with a gamma camera using bremsstrahlung radiation produced from (89)Sr beta rays. The results showed that setting the energy window at 75 keV, which is the peak formed by the characteristic X-ray of lead that is produced by the interaction of bremsstrahlung radiation and lead, is optimal for imaging. Also important are the material of the collimator and the use of an MELP collimator.
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http://dx.doi.org/10.6009/jjrt.66.764 | DOI Listing |
Appl Radiat Isot
January 2025
Radiopharmaceuticals Division, Bhabha Atomic Research Centre, Trombay, Mumbai, 400085, India.
F radioactive isotope is widely used in PET imaging for nuclear medicine. Medical linear accelerators producing high-flux bremsstrahlung beams up to 20 MeV are commonly used in radiation therapy. Hence, the production of F through photon-induced channels will reduce many of the intricacies in transportation and handling.
View Article and Find Full Text PDFPhys Rev Lett
December 2024
Laboratory of Plasma Physics (LPP), CNRS, Sorbonne Université, École Polytechnique, Institut Polytechnique de Paris, Palaiseau, France.
Energy conservation dictates that an electron with elementary charge e traversing a vacuum gap formed by electrodes maintained at potential difference U volts acquires maximum energy of eU. In many experiments electrons with energies as high as 3eU have been observed. The experimental discovery of this effect was made over 50 years ago and is still a subject of significant controversy in applications related to x-ray generation from high voltage discharges.
View Article and Find Full Text PDFRadiat Prot Dosimetry
November 2024
iRSD/CNRS, Centre Universitaire Paris-Saclay, B.P. 34, F-91898 Orsay Cedex, France.
Nuclear activation affects all operating, future, or dismantled particle accelerators used in various fields, from medical applications to industrial applications. This work is concerned with the study of the radioactivity induced in various materials (Sc, Cu, Tb, Ta, W, Au) irradiated by hard Bremsstrahlung photons from an electron beam and by secondary neutrons induced by a proton beam. In both cases, the primary beam features an 18 MeV kinetic energy.
View Article and Find Full Text PDFRep Prog Phys
November 2024
National Institute for Nuclear Physics (INFN), Section of Catania, Catania, Italy.
Med Phys
November 2024
Institut Curie, PSL Research University, Radiation Oncology Department, Proton Therapy Centre, Centre Universitaire, Orsay, France.
Background: Ultra-high dose rate (UHDR/FLASH) irradiations, along with particle minibeam therapy (PMBT) are both emerging as promising alternatives to current radiotherapy techniques thanks to their improved healthy tissue sparing and similar tumor control.
Purpose: Monte Carlo (MC) modeling of a commercial machine delivering 5-7 MeV electrons at UHDR. This model was used afterward to compare measurements against simulations for an experimental setup combining both FLASH and PMBT modalities.
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