Bioaccumulation is an important component of the exposure hazard assessment and risk assessment of organic chemicals. Screening criteria for chemical hazard used in national and international regulations are based on the paradigm that partitioning properties are the primary chemical determinants of bioaccumulation. We use a holistic multimedia perspective to evaluate the partitioning property paradigm with respect to assessing human bioaccumulation. Multimedia bioaccumulation factors (mmBAFs) for humans were modeled for hypothetical chemicals with a wide range of physical-chemical properties. Varying partitioning properties over 12 orders of magnitude (a plausible range for nonionizing organics) resulted in only modest changes in mmBAFs (a factor of ∼ 10) for all but very volatile or hydrophilic chemicals. In contrast, varying biotransformation rate constants over 6 orders of magnitude resulted in substantial differences in mmBAFs (greater than a factor of 10(9)). Our model results are supported by empirical observations of well characterized pollutants, which demonstrate that chemicals with similar partitioning properties can have very different bioaccumulation behavior. Susceptibility to biotransformation clearly determines bioaccumulation in humans for many chemicals. We conclude that a holistic multimedia perspective for bioaccumulation assessment is necessary to develop regulations, criteria, and policies that are protective of human health and the environment.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1021/es101000w | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Children Centered Care: child and parent perspectives on a multi-faceted concept for magnetic resonance imaging without anesthesia - a survey.
Pediatr Radiol
December 2024
Department of Radiology, Lillebaelt Hospital Kolding, Sygehusvej 24, 6000, Kolding, Denmark.
Background: Anxiety-provoking healthcare procedures require specific child-friendly approaches. Magnetic resonance imaging (MRI) can cause anxiety for children and general anesthesia (GA) is often used. We developed and tested a multi-faceted child-friendly concept, Children Centered Care, for MRI of children without GA.
View Article and Find Full Text PDFknowledge translation performances for public engagement on Parkinson's disease and dementia.
Front Psychol
November 2024
School of Physical and Occupational Therapy, McGill University, Montreal, QC, Canada.
Introduction: The subjective experience of illness is often overshadowed by the disease-and-cure focus of health research, contributing to the stigmatization of conditions such as Parkinson's disease and dementia. This is exacerbated by the fact that traditional means of knowledge dissemination are inaccessible to non-academic audiences, hampering meaningful dialogue with and research uptake by the broader community.
Methods: Our arts-based knowledge translation project, , brought together neuroscientists, people with Parkinson's disease or dementia, care partners and artists (musicians, dancers, circus acrobats) to co-create 2 multi-media performances based on scientific research and lived experience.
Medical student needs for e-learning: perspectives of the generation Z.
Korean J Med Educ
December 2024
Department of Medical Education, Dongguk University School of Medicine, Goyang, Korea.
Purpose: To understand medical students' perceptions and needs for e-learning to provide e-learning tailored to the needs of the generation Z students.
Methods: A focus group interview was conducted of 30 students in various years of study from five medical schools in South Korea. Subsequently, participants were also surveyed on their perceived importance of and satisfaction with e-learning.
Busy independent directors and IPO company earnings management: Evidence from China.
Heliyon
November 2024
Faculty of Management, Multimedia University, Cyberjaya, Selangor, Malaysia.
This study investigates the effect of busy independent directors on earnings management in Chinese initial public offering (IPO) companies from 2010 to 2020. Using various measures of busy independent directors, the results indicate that directors in IPO companies play a significant role in supervision and governance, thereby significantly mitigating earnings management. Busy independent directors, serving on multiple boards, may face time constraints, but, intriguingly, companies with such directors show a lower inclination for earnings manipulation.
View Article and Find Full Text PDFEnhancing accessibility: Development and usability testing of mobile application mitigating sexual harassment for visually impaired masseurs.
Assist Technol
November 2024
Department of Nursing, Faculty of Medicine, Universitas Diponegoro, Semarang, Indonesia.
This study aimed to assess the development and usability of the Visually Impaired Masseur Assistance Application (VIMAA) designed to respond to signs of danger or instances of sexual harassment experienced by Visually Impaired Masseurs (VIMs). It harmonizes Rapid Application Development (RAD) method and qualitative in-depth interviews. RAD was implemented with emphasis on four core stages: requirement identification, design workshop, construction, and implementation, while Qualitative in-depth interviews were conducted utilizing thematic analysis for usability testing.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!