With the development of cell culture technology in vitro, people have successfully cultivated osteoblast cells of typical characteristics from a number of animal skull, bone marrow, periosteum and bone tissues; studies have shown that these osteoblasts have good biological characteristics, can create bone tissue in different environments, can apply joint stand for the construction of tissue engineered bone, be implanted in the body to repair bone defects. In this article, the source of osteoblast, regulatory factor, composite graft and Chinese medicine research progress were reviewed.
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