Unlabelled: For an adequate analysis of sleep quality was assessed a new composed index wich objectively approached variate polisomnographic parameters. We used this new concept--sleep disturbances index-SDI in patients with obstructive sleep apnea (OSAS), before and after the beginning of CPAP therapy.
Material And Method: 41 patients were evaluated and for each one we calculated SDI score. All patients were split in two groups according with apnea-hipopnea index (AHI), and we correlated SDI with AHI as marker of severity of the disease and with Epworth Sleepiness Scale's scores, as an subjective evaluation. After 1 month of CPAP therapy, SDI was reevaluated.
Results: SDI is correlating with the severity of the disease: for group 1, with 5 < AHI < 15, SDI= 2.24 +/- 0.88, r = 0.53, p < 0.01 and for group 2, with AHI >15, SDI = 3.23 +/- 0.69, p < 0.01, r = 0.46. There was no significant correlation between SDI and ESS scores (r = 0.23, p < 0.01). SDI lowers significant during CPAP therapy: SDI= 1.48 +/- 0.60, respectiv SDI = 1.90 +/- 1.23.
Conclusion: The severity of OSAS is correlated with increased SDI, but can be seen interindividual variability. The effect of CPAP therapy is reflecting also in sleep quality.
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Sleep Breath
January 2025
Faculty of Medicine, Department of Neurology, University of Debrecen, Moricz Zs. str. 22, Debrecen, H-4032, Hungary.
Purpose: Obstructive sleep apnea-hypopnea syndrome (OSAHS) is the most common sleep-related breathing disorder. Longer term, repeated episodes of hypercapnia and hypoxemia during sleep are associated with inflammatory and atherosclerosis-related factors. The aim of this study was to explore the effect of continuous positive airway pressure (CPAP) therapy on cerebral vasoreactivity and early atherosclerosis in patients with severe OSAHS.
View Article and Find Full Text PDFExpert Rev Pharmacoecon Outcomes Res
January 2025
Health Technology Assessment in India (HTAIn) Regional Resource Hub, ICMR-National Institute of Epidemiology, Chennai, India.
Objectives: Obstructive sleep apnea (OSA) is a sleep-related breathing disorder characterized by recurrent episodes of nocturnal breathing cessation resulting from upper airway collapse. Given the absence of a comprehensive review of the cost-effectiveness of OSA treatments, we undertook an extensive systematic review and meta-analysis to calculate the pooled incremental net benefit (INBp).
Methods: A systematic search of PubMed, Embase, Scopus, and Tufts cost-effectiveness analysis registry was conducted.
J Clin Med
December 2024
Division of Respiratory Medicine and Rheumatology, Department of Multidisciplinary Internal Medicine, Faculty of Medicine, Tottori University, Yonago 683-8504, Japan.
: Continuous positive airway pressure (CPAP) is used to treat patients with obstructive sleep apnea (OSA) and has proven clinical efficacy for this condition. However, the objective method to determine the appropriate CPAP level for treatment is still unclear. Patients with OSA typically exhibit irregular respiratory efforts due to obstruction or narrowing of the upper airway during sleep.
View Article and Find Full Text PDFDiagnostics (Basel)
December 2024
Pediatric Clinic, Parma University Hospital, Department of Medicine and Surgery, University of Parma, 43126 Parma, Italy.
Neonatal respiratory distress syndrome (RDS) is a common and potentially life-threatening condition in preterm infants, primarily due to surfactant deficiency. Early and accurate diagnosis is critical to guide timely interventions such as surfactant administration and respiratory support. Traditionally, chest X-rays have been used for diagnosis, but lung ultrasound (LUS) has gained prominence due to its non-invasive, radiation-free, and bedside applicability.
View Article and Find Full Text PDFAndes Pediatr
October 2024
Facultad de Ciencias de la Vida, Universidad Andres Bello, Santiago, Chile.
Viral infections are the main cause of acute respiratory failure in infants, which can progress to acute respiratory distress syndrome (ARDS), with high morbidity and mortality, so it is essential to imple ment strategies that prevent this progression. Recently, it has been proposed that increased work of breathing would not only be a warning symptom during the evolution of acute respiratory failure, but also a mechanism for the progression of injury, both lungs and diaphragm, coining the concept of patient self-inflicted lung injury. Since the first reports of ARDS, the usefulness of the use of con tinuous positive airway pressure (CPAP) has been raised, a non-invasive respiratory support therapy with wide access and low cost, capable of improving oxygenation and work of breathing.
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