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Article Abstract
Purpose: To investigate the use of thermally stimulated current (TSC) to characterize disorder resulting from micronization of a crystalline drug substance. Samples processed at different milling energies are characterized, and annealing studied.
Methods: Molecular mobility in micronized drug substance was studied using TSC and compared to results from differential scanning calorimetry (DSC). The micronized drug substance TSC spectra are compared to crystalline and amorphous references.
Results: TSC shows distinct relaxation modes for micronized material in comparison to a single weak exotherm observed with DSC. Molecular mobility modes are unique for micronized material compared to the amorphous reference indicating physically distinct disorder compared to phase-separated amorphous material. Signals are ascribed as arising from crystal defects. TSC differentiates material processed at different milling energies showing reasonable correlation between the AUC of the α-relaxation and micronization energy. The annealing process of crystal defects in micronized drug appears to proceed differently for α and β relaxations.
Conclusions: TSC proves sensitive to the crystal defects in the micronized drug substance studied here. The technique is able to differentiate distinct types of disorder and can be used to characterize noncrystalline regions arising from milling processes which are physically distinct from amorphous material.
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Article Synopsis
- - The study examines how different preparation methods (milling vs. precipitation) of micron-sized posaconazole crystals affect their pharmaceutical properties, particularly their dissolution performance.
- - To avoid issues from pressure-induced changes, researchers used powder dissolution instead of the typical method that compresses powders, but faced challenges due to the low wettability of the micronized powders.
- - By pre-treating the powders with a surfactant in an aqueous solution, the study showed that even with the formation of hydrates, the differing dissolution rates provide insight into how the methods of drug preparation affect their effectiveness in the body.
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