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Microscopic augmented reality calibration with contactless line-structured light registration for surgical navigation.
Med Biol Eng Comput
January 2025
Mechanical Engineering Department, Tianjin University, No. 135, Yaguan Road, Haihe Education Park, Jinnan District, Tianjin City, 300350, China.
The use of AR technology in image-guided neurosurgery enables visualization of lesions that are concealed deep within the brain. Accurate AR registration is required to precisely match virtual lesions with anatomical structures displayed under a microscope. The purpose of this work was to develop a real-time augmented surgical navigation system using contactless line-structured light registration, microscope calibration, and visible optical tracking.
View Article and Find Full Text PDFCross-Sectional Validation of an Automated Lesion Segmentation Software in Multiple Sclerosis: Comparison with Radiologist Assessments.
AJNR Am J Neuroradiol
January 2025
From the Department of Radiology, Medical University of South Carolina, Charleston, SC, USA (MVS, HRC, WD, JHC, JAC, MGM, STS, DRR), College of Medicine, Medical University of South Carolina, Charleston, SC, USA (HW, EY).
Background And Purpose: Magnetic Resonance Imaging is widely used to assess disease burden in multiple sclerosis (MS). This study aimed to evaluate the effectiveness of a commercially available k-nearest neighbors (k-NN) software in quantifying white matter lesion (WML) burden in MS. We compared the software's WML quantification to expert radiologists' assessments.
View Article and Find Full Text PDFApplication of machine learning algorithms in predicting new onset hypertension: a study based on the China Health and Nutrition Survey.
Environ Health Prev Med
January 2025
Department of Disease Control and Prevention, The Seventh Medical Center of Chinese PLA General Hospital.
Background: Hypertension is a serious chronic disease that can significantly lead to various cardiovascular diseases, affecting vital organs such as the heart, brain, and kidneys. Our goal is to predict the risk of new onset hypertension using machine learning algorithms and identify the characteristics of patients with new onset hypertension.
Methods: We analyzed data from the 2011 China Health and Nutrition Survey cohort of individuals who were not hypertensive at baseline and had follow-up results available for prediction by 2015.
A systematic review of deep learning in MRI-based cerebral vascular occlusion-based brain diseases.
Neuroscience
January 2025
Department of Computer Engineering, Faculty of Engineering, Igdir University, 76000, Igdir, Turkey. Electronic address:
Neurological disorders, including cerebral vascular occlusions and strokes, present a major global health challenge due to their high mortality rates and long-term disabilities. Early diagnosis, particularly within the first hours, is crucial for preventing irreversible damage and improving patient outcomes. Although neuroimaging techniques like magnetic resonance imaging (MRI) have advanced significantly, traditional methods often fail to fully capture the complexity of brain lesions.
View Article and Find Full Text PDFTraditional Chinese Medicine Borneol-Based Polymeric Micelles Intracerebral Drug Delivery System for Precisely Pathogenesis-Adaptive Treatment of Ischemic Stroke.
Adv Sci (Weinh)
January 2025
Frontiers Science Center for Deep Ocean Multispheres and Earth Systems, Key Laboratory of Marine Chemistry Theory and Technology, Ministry of Education/Sanya Oceanographic Institution, Ocean University of China, Qingdao/Sanya, 266003/572024, China.
The scarcity of effective neuroprotective agents and the presence of blood-brain barrier (BBB)-mediated extremely inefficient intracerebral drug delivery are predominant obstacles to the treatment of cerebral ischemic stroke (CIS). Herein, ROS-responsive borneol-based amphiphilic polymeric NPs are constructed by using traditional Chinese medicine borneol as functional blocks that served as surface brain-targeting ligand, inner hydrophobic core for efficient drug loading of membrane-permeable calcium chelator BAPTA-AM, and neuroprotective structural component. In MCAO mice, the nanoformulation (polymer: 3.
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