In an influential study, R. J. Bootsma and P. C. W. van Wieringen (1990) argued that 2 of their 5 participants used visual information continuously during the attacking forehand drive in table tennis, its brief duration vis-à-vis the visuomotor delay notwithstanding. The authors repeated Bootsma and van Wieringen's experiment and included a condition in which vision was obscured after drive initiation. The authors replicated most of Bootsma and van Wieringen's findings but found no significant differences between the full-vision and no-vision conditions, which goes against the interpretation of these findings as evidence for continuous visual guidance. A subsequent simulation study found that a single preprogrammed muscle stimulation pattern resulted in spatiotemporal convergence similar to that observed experimentally but not in other important behavioral characteristics. The results contain no indications that visual information that becomes available after drive initiation affects arm motion and suggest that a form of model-based predictive control is operative rather than continuous visual guidance.
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http://dx.doi.org/10.1037/a0016890 | DOI Listing |
Motor Control
November 2024
Institut des Sciences du Mouvement, Aix-Marseille Université, CNRS, Marseille, France.
We develop a dynamics-based model of discrete movement for lateral manual interception capable of generating movements with realistic kinematics. For the present purposes, we focus on the situation of to-be-intercepted targets moving at constant speed along rectilinear trajectories oriented orthogonally with respect to the interception axis. The proposed phenomenological model is designed to capture the time evolution of empirically observed hand movements along the interception axis under different conditions of target arrival location and target speed-induced time pressure.
View Article and Find Full Text PDFPharmacol Res
September 2024
Amsterdam UMC Location University of Amsterdam, Center for Experimental and Molecular Medicine, Laboratory of Experimental Oncology and Radiobiology, Meibergdreef 9, Amsterdam 1105 AZ, the Netherlands; Cancer Center Amsterdam, Cancer Biology, Amsterdam, the Netherlands; Oncode Institute, Amsterdam, the Netherlands. Electronic address:
Epithelial-mesenchymal transition (EMT) has been identified as a driver of therapy resistance, particularly in esophageal adenocarcinoma (EAC), where transforming growth factor beta (TGF-β) can induce this process. Inhibitors of TGF-β may counteract the occurrence of mesenchymal, resistant tumor cell populations following chemo(radio)therapy and improve treatment outcomes in EAC. Here, we aimed to identify predictive biomarkers for the response to TGF-β targeting.
View Article and Find Full Text PDFPLoS One
May 2024
Department of Rheumatology and Clinical Immunology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
Objective: To evaluate daily physical activity (PA) in relation to psychosocial factors, such as anxiety, depression and different types of coping strategies, as well as patient- and disease-related factors in patients with axial spondyloarthritis (axSpA).
Methods: Consecutive outpatients from the Groningen Leeuwarden AxSpA (GLAS) cohort completed the modified Short Questionnaire to assess health-enhancing PA (mSQUASH), Hospital Anxiety and Depression Scale (HADS) and Coping with Rheumatic Stressors (CORS) questionnaires, as well as standardized patient- and disease-related assessments. Univariable and multivariable linear regression analyses and comparison of lowest and highest PA tertiles were performed to explore associations between the HADS, CORS, patient- and disease-related factors and PA.
J Cancer Surviv
April 2024
Department of Medical Oncology, Netherlands Cancer Institute-Antoni Van Leeuwenhoek, 1066 CX, Amsterdam, the Netherlands.
Purpose: Due to the increase in both cancer incidence and overall survival rates, more adolescents and young adults (AYAs) have to live with the effects that their cancer diagnosis and following treatments have on their bodies. This qualitative phenomenological study aimed to gain more insight into the way AYAs experience these effects and how they respond to these effects.
Methods: Semi-structured interviews with a sample of 11 AYAs with an age range of 25-41 years at the time of the interview, who were diagnosed with different types of cancer, were conducted.
J Rheumatol
July 2024
A. Visser, BSc, J.F. van Nimwegen, MD, PhD, R. Wilbrink, MD, S.C. Liefers, PhD, H. Bootsma, MD, PhD, F.G.M. Kroese, PhD, G.M. Verstappen, PharmD, PhD, University of Groningen, University Medical Center Groningen, Department of Rheumatology and Clinical Immunology, Groningen, the Netherlands;
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