Tubulo-stromal relationships were studied in rabbit and human kidneys in secondary tubulo-interstitial nephritis (TIN) of immune genesis to establish the species differences in the course and manifestations of this disease. TIN of rabbits was studied on the model of serum disease (13 animals) and in humans on renal biopsies from patients with mesangioproliferative GN (22 cases). The correlation of relative volumes of tubule structural elements characteristic for each species undergoes changes when pathologic process develops; new correlations are similar in both humans and rabbits, although the time of involvement of tubular part of nephron into the pathologic process is different. Immunohistochemically and electron-microscopically a diffuse character of the damage is shown.
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