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Observational Characterization of the Retreatment Course of Patients With Thyroid Eye Disease.
J Neuroophthalmol
January 2025
Scheie Eye Institute (YC, TL, SW, TP, PAA, G-sY, CAB, MAT), University of Pennsylvania, Philadelphia, Pennsylvania; Divisions of Neuro-ophthalmology (MAT), Oculoplastics (CAB), and Biostatistics (PAA, G-sY), Kansas Health Science Center, Kansas College of Osteopathic Medicine; and Kansas Health Science Center (GM), Kansas College of Osteopathic Medicine, Kansas, Missouri.
Background: To characterize the retreatment course of patients with thyroid eye disease (TED), who had reactivation after initial therapy with teprotumumab.
Methods: This was a single-center longitudinal cohort study of patients who received an initial course of teprotumumab for active TED and were followed for at least 6 months. Reactivation was defined as the increase of proptosis of 2 mm or more or an increase in Clinical Activity Score (CAS) of two points or more, as adapted from the Optic-X study.
Galantamine-Memantine Combination in the Treatment of Parkinson's Disease Dementia.
Brain Sci
November 2024
Department of Public Safety and Correctional Services, Baltimore, MD 21215, USA.
Parkinson's disease (PD) is a progressive neurodegenerative disorder that affects over 1% of population over age 60. It is defined by motor and nonmotor symptoms including a spectrum of cognitive impairments known as Parkinson's disease dementia (PDD). Currently, the only US Food and Drug Administration-approved treatment for PDD is rivastigmine, which inhibits acetylcholinesterase and butyrylcholinesterase increasing the level of acetylcholine in the brain.
View Article and Find Full Text PDFTrimethoprim-Sulfamethoxazole-Induced Pancytopenia: A Case Report.
Cureus
December 2024
Department of Internal Medicine, LewisGale Medical Center, Roanoke, USA.
Pancytopenia is defined as a decrease in all three myeloid cell lines, usually from a precipitating factor such as an autoimmune condition, prescription drug, or several other factors. The etiology of pancytopenia can be determined through laboratory testing, a peripheral blood smear, and a thorough history and physical examination. Trimethoprim-sulfamethoxazole (TMP/SMX, also known by the brand name of Bactrim® or Septra®) is known to cause pancytopenia in rare cases.
View Article and Find Full Text PDFCargo hitchhiking autophagy - a hybrid autophagy pathway utilized in yeast.
Autophagy
January 2025
Department of Cell and Molecular Biology, Virtua Health College of Medicine and Life Sciences, School of Osteopathic Medicine, Rowan University, Stratford, NJ, USA.
Macroautophagy is a catabolic process that maintains cellular homeostasis by recycling intracellular material through the use of double-membrane vesicles called autophagosomes. In turn, autophagosomes fuse with vacuoles (in yeast and plants) or lysosomes (in metazoans), where resident hydrolases degrade the cargo. Given the conservation of autophagy, is a valuable model organism for deciphering molecular details that define macroautophagy pathways.
View Article and Find Full Text PDFStudent correlates with interprofessional attitudes within undergraduate medical education.
BMC Med Educ
January 2025
Edward Via College of Osteopathic Medicine Auburn Campus, 910 S Donahue Dr, Auburn, AL, 36832, USA.
Background: Interprofessional education (IPE) is defined as students from two or more professions learning together to collaborate and advance health outcomes and is a required component of osteopathic medical education. Factors that influence osteopathic medical students' (OMS) interprofessional attitudes are currently unknown. This study sought to examine differences in interprofessional attitudes after completing an IPE didactic curriculum and identify specific student or curricular factors correlated with higher interprofessional attitudes.
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