AI Article Synopsis
- Researchers developed eight analogues of mitoQ and idebenone to understand how their structures affect oxygen consumption in the mitochondrial respiratory chain.
- The study found that certain mitoQ analogues strongly inhibited oxygen consumption, while modified idebenone analogues reduced it but still allowed some consumption.
- Additionally, the idebenone analogues showed effective protection for mammalian cells with depleted glutathione, indicating potential cytoprotective properties.
Article Abstract
Analogues of mitoQ and idebenone were synthesized to define the structural elements that support oxygen consumption in the mitochondrial respiratory chain. Eight analogues were prepared and fully characterized, then evaluated for their ability to support oxygen consumption in the mitochondrial respiratory chain. While oxygen consumption was strongly inhibited by mitoQ analogues 2-4 in a chain length-dependent manner, modification of idebenone by replacement of the quinone methoxy groups by methyl groups (analogues 6-8) reduced, but did not eliminate, oxygen consumption. Idebenone analogues 6-8 also displayed significant cytoprotective properties toward cultured mammalian cells in which glutathione had been depleted by treatment with diethyl maleate.
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3818132 | PMC |
| http://dx.doi.org/10.1016/j.bmc.2010.06.104 | DOI Listing |
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