AI Article Synopsis
- Researchers found that C-glucosides with a heteroaromatic ring are more stable as SGLT2 inhibitors compared to O-glucosides.
- The study identified a new compound, a thiophene derivative known as canagliflozin, which is an effective SGLT2 inhibitor.
- Canagliflozin exhibited strong anti-hyperglycemic effects in mice fed a high-fat diet.
Article Abstract
We discovered that C-glucosides 4 bearing a heteroaromatic ring formed metabolically more stable inhibitors for sodium-dependent glucose cotransporter 2 (SGLT2) than the O-glucoside, 2 (T-1095). A novel thiophene derivative 4b-3 (canagliflozin) was a highly potent and selective SGLT2 inhibitor and showed pronounced anti-hyperglycemic effects in high-fat diet fed KK (HF-KK) mice.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1021/jm100332n | DOI Listing |
Publication Analysis
Top Keywords
sodium-dependent glucose
8
glucose cotransporter
8
discovery canagliflozin
4
canagliflozin novel
4
novel c-glucoside
4
c-glucoside thiophene
4
thiophene ring
4
ring sodium-dependent
4
cotransporter inhibitor
4
inhibitor treatment
4
Similar Publications
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!