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Gold(I)-Catalyzed Nucleophilic Propargylations of Azinium Ions via Hydroxydihydroazine Intermediates.
Chemistry
January 2025
University of Nottingham, The GSK Carbon Neutral Laboratories for Sustainable Chemistry, Jubilee Campus, Triumph Road, NG7 2TU, Nottingham, UNITED KINGDOM OF GREAT BRITAIN AND NORTHERN IRELAND.
The nucleophilic propargylation of azinium ions with a propargylboronate proceeds efficiently under gold(I) catalysis. A range of N-alkylated pyridinium, quinolinium, and pyrazinium ions undergo propargylation with good yields and high regioselectivities to give various functionalized 1,4-dihydropyridines, 1,2-dihydropyridines, 1,4-dihydroquinolines, 1,2-dihydroquinolines, and 4,5-dihydropyrazines. No allenylation side-products are observed.
View Article and Find Full Text PDFNew Gold(I) Complexes as Potential Precursors for Gas-Assisted Methods: Structure, Volatility, Thermal Stability, and Electron Sensitivity.
Molecules
January 2025
Faculty of Chemistry, Nicolaus Copernicus University in Toruń, Gagarina 7, 87-100 Toruń, Poland.
We report the synthesis and characterization of new, user-friendly gold(I) [Au(μ-(NH)CCF)] coordination polymer and [AuCl(NH(NH=)CCF)] complex. These compounds were investigated for potential application as precursors in chemical vapor deposition (CVD) and focused electron/ion beam-induced deposition (FEBID/FIBID), which are additive methods to produce nanomaterials. Single-crystal X-ray diffraction, elemental analysis, and infrared spectroscopy were used to determine the complexes' composition and structure.
View Article and Find Full Text PDFSpecial Issue: "Enzymes and Enzyme Inhibitors-Applications in Medicine and Diagnosis 2.0".
Int J Mol Sci
December 2024
School of Pharmacy, Aristotle University of Thessaloniki, 54124 Thessaloniki, Greece.
The first paper in this Special Issue explores the synthesis, characterization, biological, and catalytic activities of new gold(I) and silver(I) complexes that are stabilized by caffeine derivatives and used as NHC ligands [...
View Article and Find Full Text PDFAurophilic interaction-based aggregation of gem-digold(I) aryls towards high spin-orbit coupling and strong phosphorescence.
Nat Commun
January 2025
Key Laboratory of Bioorganic Phosphorus Chemistry & Chemical Biology (Ministry of Education), Department of Chemistry, Tsinghua University, Beijing, China.
Luminescent gold(I) compounds have attracted intensive attention due to anticipated strong spin-orbit coupling (SOC) resulting from heavy atom effect of gold atoms. However, some mononuclear gold(I) compounds are barely satisfactory. Here, we unveil that low participation of gold in transition-related orbitals, caused by 6s-π symmetry mismatch, is the cause of low SOCs in monogold(I) compounds.
View Article and Find Full Text PDFNovel NMR-Based Approach to Reveal the 'Metabolic Fingerprint' of Cytotoxic Gold Drugs in Cancer Cells.
J Proteome Res
January 2025
Department of Chemistry "Ugo Schiff", University of Florence, Sesto Fiorentino 50019, Italy.
A combination of pathway enrichment and metabolite clustering analysis is used to interpret untargeted H NMR metabolomics data, enabling a biochemically informative comparison of the effects induced by a panel of known cytotoxic gold(I) and gold(III) compounds in A2780 ovarian cancer cells. The identification of the most dysregulated pathways for the major classes of compounds highlights specific chemical features that lead to common biological effects. The proposed approach may have broader applicability to the screening of metal-based drug candidate libraries, which is always complicated by their multitarget nature, and support the comprehensive interpretation of their metabolic actions.
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