AI Article Synopsis
- The study discusses the design of a custom irradiation device for research on human tumor xenografts, using a commercial X-ray tube and a lead collimator to allow simultaneous treatment of two animals.
- It focuses on dosimetry and methodology specifically for radiotherapy targeting non-small cell lung cancer xenograft tumors in a nude rat model.
- The results confirm the device's feasibility for investigating both tumor and non-tumor lesions in small animal studies.
Article Abstract
Studies that investigate the radiation of human tumour xenografts require an appropriate radiation source and highly standardized conditions during radiation. This work reports on the design of a standardized irradiation device using a commercially available X-ray tube with a custom constructed lead collimator with two circular apertures and an animal bed plate, permitting synchronous irradiation of two animals. Dosimetry and the corresponding methodology for radiotherapy of human non-small cell lung cancer xenograft tumours transplanted to and growing subcutaneously on the right lower limb in a nude rat model were investigated. Procedures and results described herein prove the feasibility of use of the device, which is applicable for any investigation involving irradiation of non-tumorous and tumorous lesions in small animals.
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| http://dx.doi.org/10.1007/s12038-010-0024-4 | DOI Listing |
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