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Fecal Immunochemical Test Positivity Thresholds: An International Survey of Population-Based Screening Programs.
Dig Dis Sci
November 2024
Flinders University, Adelaide, SA, Australia.
Background: The fecal immunochemical test for hemoglobin (FIT) is now a widely used non-invasive test in population-based organized screening programs for colorectal neoplasia. The positivity thresholds of tests currently in use are based on the fecal hemoglobin concentration (f-Hb), but the rationale for the adopted thresholds are not well documented. To understand current global usage of FIT in screening programs we conducted an international survey of the brands of FIT used, the f-Hb positivity threshold applied and the rationale for the choice.
View Article and Find Full Text PDFAssessment of potential myopia risk factors, including chronotype, in Estonian adolescents: a cross-sectional study.
BMC Ophthalmol
November 2024
Eye Clinic, East Tallinn Central Hospital, Ravi 18, Tallinn, 10138, Estonia.
Background: Myopia is a growing healthcare concern worldwide. Increasing evidence suggests that sleep and circadian rhythms may be associated with myopia. Furthermore, the risk factors of myopia have not been studied in the Estonian population to date.
View Article and Find Full Text PDFInvited reply letter: optimal techniques of ultrasound-guided superficial and deep parasternal intercostal plane blocks - a cadaveric study.
Reg Anesth Pain Med
September 2024
Excellence in Osteology Research and Training Center (ORTC), Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand.
Immediate sequential bilateral cataract surgery: Prevalence, attitudes and concerns Among Italian ophthalmologists.
Eur J Ophthalmol
August 2024
Department of Medical, Surgical Sciences and Health, University of Trieste, Trieste, Italy.
Article Synopsis
- The study examines current practices of immediate sequential bilateral cataract surgery (ISBCS) among Italian ophthalmologists and their future attitudes toward it.
- A multicenter survey was conducted with 246 of 2300 invited participants, revealing that 63.4% perform ISBCS, mostly on an occasional basis, with over half interested in making it routine.
- The main advantages for ISBCS were identified as procedure efficiency and patient benefits, while concerns over risks like bilateral endophthalmitis and legal issues hinder broader adoption.
Immune and gene-expression profiling in estrogen receptor low and negative early breast cancer.
J Natl Cancer Inst
December 2024
Oncology 2, Veneto Institute of Oncology IOV-IRCCS, Padova, Italy.
Background: The cutoff of <1% positive cells to define estrogen receptor (ER) negativity by immunohistochemistry (IHC) in breast cancer (BC) is debated. We explored the tumor immune microenvironment and gene-expression profile of patients with early-stage HER2-negative ER-low (ER 1%-9%) BC, comparing them to ER-negative (ER <1%) and ER-intermediate (ER 10%-50%) tumors.
Methods: Among 921 patients with early-stage I-III, ER ≤50%, HER2-negative BCs, tumors were classified as ER-negative (n = 712), ER-low (n = 128), or ER-intermediate (n = 81).
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