Purpose: To determine the expected ablation zone size and associated isotherms when using clinically available percutaneous cryoprobes for pulmonary cryoablation in a porcine lung model.
Materials And Methods: Seven ablations were performed in the lungs of three adult pigs using clinically available 2.4-mm cryoprobes (Endocare, Inc, Irvine, California) and a 10-minute double-freeze protocol. Five 18-gauge thermocouples were positioned at 5-mm increments (ie, 5, 10, 15, 20, and 25 mm) from the cryoprobe. Real-time tissue temperatures were recorded during the cryoablation. The isotherms obtained during the ablation and the pathological ablation zones were measured.
Results: The pathologic zone of complete necrosis had a mean diameter of 2.4 + or - 0.2 cm, with a mean area of 4.6 + or - 0.6 cm(2) and a circularity of 0.95 + or - 0.04. In comparison, the mean diameter (+ or - standard deviation) of the 0 degrees C, -20 degrees C, and -40 degrees C isotherms were 3.1 + or - 0.2 cm, 2.3 + or - 0.3 cm, and 1.8 + or - 0.4 cm, respectively. The -20 degrees C isotherm was most closely related to the pathologic zone of ablation.
Conclusions: This study establishes the temperature isotherms and associated ablation zone size that can be expected with modern percutaneous cryoprobes in an in vivo porcine lung model.
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| http://dx.doi.org/10.1016/j.jvir.2010.04.029 | DOI Listing |
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