A domino carbopalladation-carbonylation sequence for substrates possessing beta-hydrogens is explored. This allows for the construction of complex architectures with vicinal stereocenters in a concise and rapid fashion via the stereocontrolled formation of two carbon-carbon bonds. An integral aspect of this domino reaction is the ability to control beta-hydride elimination of the organopalladium intermediate and instead form the carbonylation product.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1021/ol1009703 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Domino carbopalladation-carbonylation: generating quaternary stereocenters while controlling beta-hydride elimination.
Org Lett
September 2010
Organic Chemistry, KTH Chemical Science and Engineering, Royal Institute of Technology, SE-10044 Stockholm, Sweden.
A domino carbopalladation-carbonylation sequence for substrates possessing beta-hydrogens is explored. This allows for the construction of complex architectures with vicinal stereocenters in a concise and rapid fashion via the stereocontrolled formation of two carbon-carbon bonds. An integral aspect of this domino reaction is the ability to control beta-hydride elimination of the organopalladium intermediate and instead form the carbonylation product.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!