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Eliminating malaria transmission requires targeting immature and mature gametocytes through lipoidal uptake of antimalarials.
Nat Commun
November 2024
Department of Biochemistry, Genetics and Microbiology, University of Pretoria, Hatfield, Pretoria, 0028, South Africa.
Novel antimalarial compounds targeting both the pathogenic and transmissible stages of the human malaria parasite, Plasmodium falciparum, would greatly benefit malaria elimination strategies. However, most compounds affecting asexual blood stage parasites show severely reduced activity against gametocytes. The impact of this activity loss on a compound's transmission-blocking activity is unclear.
View Article and Find Full Text PDFMorphological Characterization of Culex Quinquefasciatus (Diptera: Culicidae) Pupae in the Eastern Province of Saudi Arabia.
Microsc Res Tech
February 2025
Department of Zoology, College of Science, King Saud University, Riyadh, Saudi Arabia.
Article Synopsis
- Over the past three decades, mosquito-borne diseases like lymphatic filariasis have become a significant public health concern globally, especially in tropical regions such as Saudi Arabia, due to the spread of parasites like Wuchereria bancrofti and Brugia malayi transmitted by mosquitoes like Culex quinquefasciatus.
- * Culex quinquefasciatus also serves as a vector for various viruses and protozoa, necessitating better species identification, particularly of their immature pupal stages, which are currently under-researched.
- * This study focused on examining the morphological features of Cx. quinquefasciatus pupae to improve identification, helping entomologists more effectively classify mosquitoes during virus outbreaks
Investigating the association between household exposure to Anopheles stephensi and malaria in Sudan and Ethiopia: A case-control study protocol.
PLoS One
September 2024
Department of Vector Biology, Liverpool School of Tropical Medicine, Liverpool, United Kingdom.
Background: Endemic African malaria vectors are poorly adapted to typical urban ecologies. However, Anopheles stephensi, an urban malaria vector formerly confined to South Asia and the Persian Gulf, was recently detected in Africa and may change the epidemiology of malaria across the continent. Little is known about the public health implications of An.
View Article and Find Full Text PDFImmature dendritic cell-targeting mRNA vaccine expressing PfCSP enhances protective immune responses against liver infection.
Res Sq
July 2024
Department of Molecular Microbiology and Immunology, Johns Hopkins School of Public Health, Baltimore, MD, 21205, USA.
Resurgence in malaria has been noted in 2022 with 249 million clinical cases resulting in 608,000 deaths, mostly in children under five. Two vaccines, RTS, S, and more recently R21, targeting the circumsporozoite protein (CSP) are recommended by the WHO but are not yet widely available. Strong humoral responses to neutralize sporozoites before they can infect the hepatocytes are important for vaccine-mediated protection.
View Article and Find Full Text PDFProteomes of plasmodium knowlesi early and late ring-stage parasites and infected host erythrocytes.
J Proteomics
June 2024
Emory Vaccine Center and Yerkes National Primate Research Center, Emory University, Atlanta, GA 30322, USA; Division of Infectious Diseases, Department of Medicine, Emory University School of Medicine, Emory University, Atlanta, GA 30322, USA.
The emerging malaria parasite Plasmodium knowlesi threatens the goal of worldwide malaria elimination due to its zoonotic spread in Southeast Asia. After brief ex-vivo culture we used 2D LC/MS/MS to examine the early and late ring stages of infected Macaca mulatta red blood cells harboring P. knowlesi.
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