AI Article Synopsis
- Down syndrome (DS) is the most prevalent chromosomal disorder found in live-born infants.
- Respiratory tract infections are a major cause of death for individuals with DS at any age.
- Although there have been many studies on immune system abnormalities in DS, there hasn't been a comprehensive review on how these immune issues affect respiratory infections in these children.
Article Abstract
Down syndrome (DS) is the most common chromosomal abnormality among live-born infants. Respiratory tract infections are the most important cause of mortality in individuals with DS at all ages. In recent decades several studies have been performed to elucidate abnormalities of the immune system in DS. However, the influence of the immune system on the occurrence of respiratory tract infections in these children has never been reviewed.
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| http://dx.doi.org/10.1016/j.micinf.2010.05.007 | DOI Listing |
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