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Floating the Flap: Suspension of Soft Tissue Free Flap Over External Fixation-Guided Bone Transport: A Novel Technique.
JBJS Case Connect
January 2025
Department of Surgery, Plastic and Reconstructive Surgical Service, Memorial Sloan Kettering Cancer Center, New York, New York.
Case: Wide resection of a synovial sarcoma of the anteromedial distal leg involving the dimetaphyseal tibia and posterior tibial tendon produced an 8.5-cm osseous defect. To keep the free flap from invaginating into the defect and prevent kinking of the anastomosis, six 1.
View Article and Find Full Text PDFAwakening not associated with an increased rate of cortisol secretion.
Proc Biol Sci
January 2025
Laboratory for Integrative Neuroscience and Endocrinology, University of Bristol, Bristol BS1 3NY, UK.
Cortisol is released upon activation of the hypothalamic-pituitary-adrenal axis, varies across the day, possesses an underlying diurnal rhythm and is responsive to stressors. The endogenous circadian peak of cortisol occurs in the morning, and increases in cortisol observed post-awakening have been named the cortisol awakening response (CAR) based on the belief that the act of waking up stimulates cortisol secretion. However, objective evidence that awakening induces cortisol secretion is limited.
View Article and Find Full Text PDFUnveiling STRs instability in a colorectal cancer FFPE sample: a case report.
Int J Legal Med
January 2025
Department of Diagnostics and Public Health, Section of Forensic Medicine, Forensic Genetics Lab, University of Verona, Verona, Italy.
In forensic genetics, sometimes formalin-fixed paraffin-embedded (FFPE) biopsy material taken during life is the only biological sample available for individual identification or paternity testing. In most cases, this biological tissue is characterized by the presence of tumor cells characterized by instability and loss of heterozygosity of microsatellites (MSI/LOH) compared to the DNA present in cells of normal tissue.In this case report, two FFPE samples from the same male subject were available for genetic investigation: one sample with colorectal cancer tissue and the other with normal tissue (no cancerous histopathological features).
View Article and Find Full Text PDFCustomized Soft Tissue Free Flaps in Head and Neck Reconstruction.
Oral Maxillofac Surg Clin North Am
November 2024
Oral and Maxillofacial Surgery, Charleston Area Medical Center, Charleston, WV 24314, USA.
The integration of imaging technologies such as computed tomography angiography and color Doppler ultrasonography are transforming soft tissue free flap reconstruction. The search for thinner and more refined flaps has expanded indications for flaps harvested from donor sites that were not commonly used in head and neck reconstruction. This article explores how these tools and techniques facilitate precise flap selection, thickness, and design customization based on detailed patient preoperative perforator anatomy and vascular configuration mapping.
View Article and Find Full Text PDFColorectal Cancer Recurrence Prediction Using a Tissue-Free Epigenomic Minimal Residual Disease Assay.
Clin Cancer Res
October 2024
Department of Gastroenterology and Gastrointestinal Oncology, National Cancer Center Hospital East, Chiba, Japan.
Article Synopsis
- The study highlights the effectiveness of a noninvasive assay (Guardant Reveal) that detects circulating tumor DNA (ctDNA) in patients with resected colorectal cancer, which can predict recurrence without needing prior tissue tests.
- Results showed that the assay provided sensitive and specific detection of minimal disease, with an impressive 81% sensitivity in later-stage colon cancer, and identified recurrences up to 5.3 months earlier than traditional methods.
- The findings suggest that ctDNA testing could significantly enhance clinical management for stage II and higher colorectal cancer patients by offering a quicker and more accessible way to assess disease status.
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