In this issue of Cell Stem Cell, Chen et al. (2010) and Ohgushi et al. (2010) report that Rho-mediated actomyosin contractility underlies the proclivity of human embryonic stem cells to undergo apoptosis upon dissociation or during low-density propagation, a property that challenges their in vitro isolation and manipulation.
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| http://dx.doi.org/10.1016/j.stem.2010.07.002 | DOI Listing |
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Continuing Professional Development and Medical Education, Faculty of Medicine, Dalhousie University, Halifax, Canada.
The prospect of death is everywhere, but seldom directly addressed, in undergraduate medical education (UGME). Despite calls for UGME curricula to address the complex social and emotional aspects of death and dying, most curricula focus on biomedical, legal, and logistical aspects, or concentrate these topics within palliative care content and/or in simulations with simulated patients and manikins. We aimed to add to death education scholarship by exploring the complexities of death and dying within two dimensional simulations-i.
View Article and Find Full Text PDFBrain death as a moral definition and an act of love: the tale of Moon, Nehviel and Fate.
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April 2023
Department of Medical and Surgical Specialties, Radiological Sciences and Public Health, University of Brescia, Brescia, Italy -
The vital status of people with a destroyed brain is one of the most discussed topics in medical literature. According to the current legal narrative, people whose brain is destroyed are dead. Nevertheless, a clear biological rationale to support with certainty such a narrative is still lacking.
View Article and Find Full Text PDFIn Praise of Wisdom: A Morality Tale.
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Department of Psychiatry, University of Manitoba, Winnipeg, Manitoba, Canada.
Wisdom and intelligence work best in unison. What happens, however, when seemingly smart people fail to exercise wisdom, either in social discourse, clinical encounters, or even within the broader political arena? This morality tale, in which Wisdom and Smart take each other on in a debate at a local bar, illustrates the fallout, when these two are not on the same page.
View Article and Find Full Text PDFDifferential effects of internal tagging depending on depth treatment in Atlantic salmon: a cautionary tale for aquatic animal tag use.
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Institute of Marine Research, Matre Research Station, Matredal, Norway.
Electronic tags are widespread tools for studying aquatic animal behavior; however, tags risk behavioral manipulation and negative welfare outcomes. During an experiment to test behavioral differences of Atlantic salmon in different aquaculture cage types, including ones expected to elicit deeper swimming behavior, we found negative tagging effects depending on whether cages were depth-modified. In the experiment, data storage tags implanted in Atlantic salmon tracked their depth behavior and survival in unmodified sea-cages and depth-modified sea-cages that forced fish below or into a narrow seawater- or freshwater-filled snorkel tube from a 4 m net roof to the surface.
View Article and Find Full Text PDFA country's healthcare system-the protection and healing of some its weakest people, its sick and injured-could be considered to be one of the most definitive expressions of its national morality. In recent decades, Ireland has experienced profound cultural changes; from a mostly monocultural and religious society to a multi-ethnic one, where secular ideas predominate. Economically, it is largely neoliberal, with one of the world's most open economies, and one of its lowest corporate tax rates; though there is also a welfare state.
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