Therapeutic vaccination with replication deficient adenovirus expressing a viral antigen linked to invariant chain was recently found to markedly delay the growth of B16.F10 melanomas expressing the same antigen; however, complete regression of the tumors was never observed. Here we show that the delay in tumor growth can be converted to complete regression and long-term survival in 30-40% of the mice by a booster vaccination plus combinational treatment with agonistic anti-CD40 monoclonal antibodies (mAb) and anti-CTLA-4 mAb. Regarding the mechanism underlying the improved clinical effect, analysis of the tumor-specific response revealed a significantly prolonged tumor-specific CD8 T cell response in spleens of the mice receiving the combinational treatment compared with mice receiving either treatment individually. Matching this, CD8 T cell depletion completely prevented tumor control. These results indicate that even with a strong tumor vaccine candidate, combinatorial treatment may be required to obtain clinically relevant results.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.vaccine.2010.07.066 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Extreme Heat Stress and Unplanned Hospital Admissions.
Pediatrics
December 2024
Child Population and Translational Health Research, Children's Hospital Westmead Clinical School, Faculty of Medicine and Health, The University of Sydney, Camperdown, New South Wales, Australia.
Objectives: The burden and health impact of heat stress on child hospitalization is limited. This study aims to investigate associations between extreme heat stress exposure based on a Universal Thermal Climate Index (UTCI), emergency department (ED) visits, and ED visits that translate into unplanned hospital admissions.
Methods: This population-based case-crossover study included all ED visits and unplanned hospital admissions among children and adolescents aged 0 to 18 years from New South Wales, Australia, from July 2001 to June 2020.
Eating Disorders in Taekwondo Athletes: The Contribution of Coach Behavior, Body Satisfaction, and Goal Orientation.
Sports (Basel)
November 2024
MEDILAB, 21000 Split, Croatia.
Taekwondo is a weight-classified combat sport. Taekwondo athletes often resort to restrictive eating behaviors and weight reduction, especially just before competitions, which, in the long run, endanger their physical and mental health. This study aimed to determine the incidence of eating disorder (ED) symptoms regarding sex, age, and competitive level categories and examine the correlation and contribution of coach behavior, body satisfaction, and goal orientation to the development of ED symptoms in different subgroups.
View Article and Find Full Text PDFOcular adnexal lymphoma - A single-center observational study of survival outcomes.
Indian J Ophthalmol
December 2024
Department of Orbit, Oculoplasty, Ocular Oncology and Ocular Prosthesis, Aravind Eye Hospital and Post Graduate Institute of Ophthalmology, Madurai, Tamil Nadu, India.
Purpose: This study aims to comprehensively characterize the clinical, demographic, and histopathological features of ocular adnexal lymphoma (OAL) and assess their impact on patients' survival outcomes.
Methods: A total of 123 patients were included in the study; of these, 93 patients were selected for survival analysis. Survival data were analyzed using the Kaplan-Meier test, and correlation was assessed through the log-rank test and Cox regression analysis.
FastQAFPN-YOLOv8s-Based Method for Rapid and Lightweight Detection of Walnut Unseparated Material.
J Imaging
December 2024
College of Big Data and Intelligent Engineering, Southwest Forestry University, Kunming 650224, China.
Walnuts possess significant nutritional and economic value. Fast and accurate sorting of shells and kernels will enhance the efficiency of automated production. Therefore, we propose a FastQAFPN-YOLOv8s object detection network to achieve rapid and precise detection of unsorted materials.
View Article and Find Full Text PDFBetter Quality of Life in Physically Active Adults Regardless of Age.
Geriatrics (Basel)
December 2024
Department of Balneoclimatology and Biological Regeneration, Chair of Physiotherapy, School of Health Sciences in Katowice, Medical University of Silesia in Katowice, Medyków 12 Street, 40-752 Katowice, Poland.
Quality of life (QOL) has become an important public health issue. Adults presenting better QOL have shown reduced mortality and risk of chronic diseases and better mental health. Regular physical activity (PA) is consistently associated with a number of health benefits in older adults, including betted QOL, which is a key component of healthy aging.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!